نتایج جستجو برای: kindling development

تعداد نتایج: 1416637  

Journal: :physiology and pharmacology 0
zohre ghotbeddin dept. physiology, faculty of medical science, tarbiat modares university, tehran, iran javad mirnajafi-zadeh dept. physiology, faculty of medical science, tarbiat modares university, tehran, iran saeed semnanian dept. physiology, faculty of medical science, tarbiat modares university, tehran, iran mahyar janahmadi neuroscience research center and department of physiology, medical school, shahid beheshti university of medical sciences. evin, tehran, iran. po. box 19615-1178.

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...

Journal: :Acta neurobiologiae experimentalis 1989
A Sobieszek

The formation and subsequent development of after-discharges (ADs) and spontaneous interictal spikes was investigated in a group of ten kindled cats. The electrodes used for electrical stimulation and EEG recording were located in various parts of the hippocampal formation: in the hippocampal gyrus, dentate gyrus, subiculum and entorhinal cortex. The animals were stimulated once daily with 1 s ...

Journal: :The Journal of biological chemistry 2003
Dmitriy M Chudakov Alexei V Feofanov Nikolay N Mudrik Sergey Lukyanov Konstantin A Lukyanov

asCP, the unique green fluorescent protein-like nonfluorescent chromoprotein from the sea anemone Anemonia sulcata, becomes fluorescent ("kindles") upon green light irradiation, with maximum emission at 595 nm. The kindled protein then relaxes to a nonfluorescent state or can be "quenched" instantly by blue light irradiation. In this work, we used asCP mutants to investigate the mechanism under...

Journal: :European Psychiatry 2023

Introduction Research on life stress in bipolar disorder largely fails to account for the possibility of a dynamic relationship between psychosocial and episode initiation. The kindling hypothesis states that over course recurrent affective disorders, there is weakening temporal major initiation could reflect either progressive sensitization or autonomy stress. Objectives To explore concept Kin...

Journal: :physiology and pharmacology 0
maryam zeraati det. physiology, faculty of medicine, tarbiat modares university, tehran, iran javad mirnajafi-zadeh det. physiology, faculty of medicine, tarbiat modares university, tehran, iran mohammad javan saeed semnanian simin namvar

introduction: considering high prevalence of epileptic disease and considering that 40 percent of epileptic patients are resistant to drug therapy, it needs more researches to find new therapeutic ways. lfs is among the new methods for epilepsy treatments. one possible mechanism involved in the anticonvulsant effect of lfs is increased adenosine. therefore, in this study the role of adenosine p...

2004
Kazuyoshi Matsuda Shin-ichi Yoshioka Junji Takasu Hideaki Mitani Ryuzo Kawahara

Abbreviations: AD, after-discharge; ADD, AD duration; ADT, AD threshold; PS, primary site; PTE, positive transfer effect; SS, secondary site Kindling is the progression of behavioral and electrographical seizure induced by repeated activation of neural pathways with initial subclinical stimulations (Goddard et al., 1969). Once kindling is established, the kindling effect is sustained for a long...

2013
Idrish Ali Patrick O'Brien Gaurav Kumar Thomas Zheng Nigel C. Jones Didier Pinault Chris French Margaret J. Morris Michael R. Salzberg Terence J. O'Brien

Early life stress results in an enduring vulnerability to kindling-induced epileptogenesis in rats, but the underlying mechanisms are not well understood. Recent studies indicate the involvement of thalamocortical neuronal circuits in the progression of kindling epileptogenesis. Therefore, we sought to determine in vivo the effects of early life stress and amygdala kindling on the firing patter...

Ali Moghimi, Mohammad Mohammad-Zadeh, Seyed Mehdi Beheshti Nasr,

Introduction: Minocycline is a derivative of tetracycline that has anti-inflammatory, antiappoptic, antioxidant and neuroprotective effects. Since there is a relationship between cell death and seizure, the aim of this study was to examine the role of minocycline in development of amygdala kindling in Wistar rats. Methods: In this study, 21 rats were divided into three groups. After sterotax...

J Narenjkar M Sayyah M Yousefi-Pour

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

Journal: :Brain : a journal of neurology 2007
Tianfu Li Julius A Steinbeck Theresa Lusardi Philipp Koch Jing Q Lan Andrew Wilz Michaela Segschneider Roger P Simon Oliver Brüstle Detlev Boison

Epilepsy therapy is largely symptomatic and no effective therapy is available to prevent epileptogenesis. We therefore analysed the potential of stem cell-derived brain implants and of paracrine adenosine release to suppress the progressive development of seizures in the rat kindling-model. Embryonic stem (ES) cells, engineered to release the inhibitory neuromodulator adenosine by biallelic gen...

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