genistein is a soya isoflavone, which is found naturally in legumes, such as soybeans and chickpeas. the intraperitoneal administration of the optimum dose (200 mg/kg) of genistein 24 h and 15 minbefore irradiation (8 gy at a dose rate of 1.02 gy/min) recovered the deficit in protein content (28.63±1.44%) and the dna content (21.61±8.19%) if an average of 5 intervals of autopsies 1st, 3rd, 7th,...

diabetic retinopathy is the lead among causes of blindness in north america. glucose-induced endothelial injury is the most important cause of diabetic retinopathy and other vascular complications. extracellular signal-regulated kinase 5 (erk5), also known as big mitogen-activated protein kinase 1 (bmk1), is a member of mitogen-activated protein kinases (mapk) family. physiologically, it is cri...

objective(s): the rotavirus nonstructural protein 4 (nsp4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase c-dependent and phospholipase c-independent pathways in infected cells. it is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

abstract inflammatory pseudotumour describes as a wide range of neoplastic and reactive lesions. one of the rare presentations of these tumors is found in the salpinx. this case report characterizes a thirty six year old woman with a history of left sided abdominal pain for a few months. further examinations revealed that she had a complex cyst in her left salpinx. the patient had normal levels...

hallervorden-spatz syndrome is a disorder characterized by dystonia, parkinsonism, and iron accumulation in the brain. the disease is caused by mutations in gene encoding pantothenate kinase 2 (pank2) and patients have pantothenate kinase-associated neurodegeneration. we present an 8-year-old boy with progressive muscle dystonia, neuroregression, frequent fall and multiple injury marks of diffe...

Background: The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase. Methods: creatine kinase was isolated from human sperm homogenates after chromatography on a DEAE cellulose column. Results: At 60 µg ml-1 metal concentration, 70% of the creatine kinase activi...

hereditary inclusion body myopathy (hibm) is an adult-onset hereditary myopathy, usually with distal onset and quadriceps sparing. this myopathy is autosomal recessive and associated to upd-n-acetylglucosamine-2-epimerase/n-acetylmannosamine kinase (gne) gene mutations. in this study, we report a novel gne homozygous point mutation c.1834t>g that results in amino acid substitution of cysteine 6...

Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

Objective(s) Inhibitors of p38 MAP kinase are considered as suitable target in the treatment of inflammatory diseases such as rheumatoid arthritis and bowel inflammatory diseases. The development of 5-alkylthio-1-aryl-2-(4-pyridinyl) triazoles as inhibitors of p38 MAP kinase is described. These are analogues of 4- pyridinyl imidazole p38 MAP kinase inhibitor reported by Merck Research Laborator...