نتایج جستجو برای: kidney injury molecule 1

تعداد نتایج: 3210891  

2014
S.K. Bland O. Côté M.E. Clark J. DeLay D. Bienzle

BACKGROUND Kidney disease (KD) is common in older cats and presumed to arise from subclinical kidney injuries throughout life. Sensitive markers for detecting kidney injury are lacking. Kidney injury molecule 1 (KIM-1) is a useful biomarker of kidney injury in humans and rodents. HYPOTHESIS/OBJECTIVES Feline KIM-1 is conserved across species, expressed in kidney, and shed into urine of cats w...

2014
Xinghua Shao Lei Tian Weijia Xu Zhen Zhang Chunlin Wang Chaojun Qi Zhaohui Ni Shan Mou

BACKGROUND Urinary Kidney Injury Molecule 1 (KIM-1) is a proximal tubular injury biomarker for early detection of acute kidney injury (AKI), with variable performance characteristics depending on clinical and population settings. METHODS Meta-analysis was performed to assess the diagnostic value of urinary KIM-1 in AKI. Relevant studies were searched from MEDLINE, EMBASE, Pubmed, Elsevier Sci...

Journal: :American journal of physiology. Renal physiology 2006
Vishal S Vaidya Victoria Ramirez Takaharu Ichimura Norma A Bobadilla Joseph V Bonventre

Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influences and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1), a...

2016
Mildred Zulu Trevor Kaile Timothy Kantenga Chisanga Chileshe Panji Nkhoma Musalula Sinkala

INTRODUCTION Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of ...

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