The kidney is the target of numerous xenobiotic toxicants, including environmental chemicals. Anatomical, physiological, and biochemical features of the kidney make it particularly sensitive to many environmental compounds. Factors contributing to the sensitivity of the kidney include: large blood flow, the presence of a variety of xenobiotic transporters and metabolizing enzymes, and concentra...

Piscirickettsia salmonis is the intracellular bacterium that causes salmonid rickettsial septicemia, an infectious disease that kills millions of farmed fish each year. The mechanisms used by P. salmonis to survive and replicate within host cells are not known. Piscirickettsiosis causes severe necrosis of hematopoietic kidney. Microarray-based experiments with QPCR validation were used to ident...

This unit provides methods for analyzing uptake in rat kidney proximal tubule cells and rat kidney cortical mitochondria, preparation of proximal tubule cells and cortical mitochondria, and HPLC analysis of glutathione and related compounds.

Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous ...

Antioxidant activity of aerial part of Cytisus scoparius, Link (Family Leguminosae) was studied both by in vitro and in vivo models. Different concentrations of different extracts of chloroform, ethyl acetate, methanol and hydroalcoholic extracts of plant were investigated for in vitro antioxidant activity using the thiocyanate method. The hydroalcoholic extract exhibited highest inhibitory ac...

The present study was aimed at elucidating the protective effect of ferulic acid (FA), a natural polyphenol against nicotine-induced tissue damage, including lung, liver and kidney of experimental rats. Female albino rats of Wistar stain were used for the experimental study. Lung toxicity was induced by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22...

antioxidant activity of aerial part of cytisus scoparius, link (family leguminosae) was studied both by in vitro and in vivo models. different concentrations of different extracts of chloroform, ethyl acetate, methanol and hydroalcoholic extracts of plant were investigated for in vitro antioxidant activity using the thiocyanate method. the hydroalcoholic extract exhibited highest inhibitory act...

Ischemia?reperfusion injury (IRI), also called reoxygenation injury, is the outcome of inflammatory processes and oxidative damage through induction stress. In clinical setting, IRI contributes to severe hepatic including liver cell death by apoptosis ferroptosis. Ferroptosis a novel type in that involves small molecules inhibit glutathione biosynthesis or peroxidase 4 (GPX4), which glutathione...