نتایج جستجو برای: khalil mardom bak

تعداد نتایج: 3778  

2016
Sweta Iyer Khatira Anwari Amber E Alsop Wai Shan Yuen David C S Huang John Carroll Nicholas A Smith Brian J Smith Grant Dewson Ruth M Kluck

During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-activated Bak to induce conformational change, oligomerization, and cytochrome c ...

Journal: :Investigative ophthalmology & visual science 2005
Komei Okabe Hideya Kimura Junko Okabe Aki Kato Hideo Shimizu Takashi Ueda Shouichi Shimada Yuichiro Ogura

PURPOSE To investigate the effect and safety of benzalkonium chloride on transscleral drug delivery in the rabbit after continuous intrascleral administration. METHODS Betamethasone 21-phosphate (BP) aqueous solutions, with or without benzalkonium chloride (BAK), were continuously administered to albino rabbit sclera with an osmotic pump for 1 week. The BP concentrations in the aqueous humor,...

2009
Michael B Horsley Malik Y Kahook

PURPOSE To quantify changes in tear break-up time (TBUT), corneal staining and ocular surface disease index (OSDI) in glaucoma patients after switching therapy from latanoprost with 0.02% benzalkonium chloride (BAK) to travoprost with sofZia(). METHODS Prospective consecutive case series evaluating patients before and 8 weeks after switching from latanoprost with BAK to travoprost with sofZia...

2011
David A. Ammar Malik Y. Kahook

PURPOSE We investigated the potential short and long-term effects in cultured human trabecular meshwork (TM) cells of various topical glaucoma formulations containing different preservatives. METHODS We tested the fixed combination medications 0.004% travoprost plus 0.5% timolol preserved with either 0.015% benzalkonium chloride (BAK; DuoTrav®), or with 0.001% polyquad (PQ; DuoTrav(®) BAK-fre...

2015
Yanwei Luo Xinye Wang Heran Wang Yang Xu Qiuyuan Wen Songqing Fan Ran Zhao Shihe Jiang Jing Yang Yukun Liu Xiayu Li Wei Xiong Jian Ma Shuping Peng Zhaoyang Zeng Xiaoling Li Joshua B. Phillips Guiyuan Li Ming Tan Ming Zhou Javier S Castresana

Breast cancer has become the leading cause of cancer-related death among women. A large number of patients become resistant to drug chemotherapy. Paclitaxel (Taxol) is an effective chemotherapeutic agent used to treat cancer patients. Taxol has been widely used in human malignancies including breast cancer because it can stabilize microtubules resulting in cell death by causing an arrest during...

Journal: :The EMBO journal 2015
Franziska Todt Zeynep Cakir Frank Reichenbach Frederic Emschermann Joachim Lauterwasser Andrea Kaiser Gabriel Ichim Stephen W G Tait Stephan Frank Harald F Langer Frank Edlich

The Bcl-2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro-survival Bcl-2 proteins control Bax by constant retrotranslocation into the cytosol of healthy cells. The stabilization of cytosolic Bax raises the question whether the functionally redundant but largely mitochondrial Bak shares this level of regulation. Here we report that Bak is...

Journal: :The Journal of Experimental Medicine 2006
Yanan Zhu Xinqi Liu David Hildeman Fred W. Peyerl Janice White Elenora Kushnir John Kappler Philippa Marrack

The introduction of antigen into animals causes antigen-specific T cells to divide and then die. Activated T cell death requires either of the death effector molecules, Bak or Bax. When T cells die, Bak and Bax change their conformations, a phenomenon that is thought to be required for Bak or Bax to drive cell death. Here we show that Bak changes conformation before activated T cells die, as de...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Tullia Lindsten Jeffrey A Golden Wei-Xing Zong Jeremy Minarcik Marian H Harris Craig B Thompson

The proapoptotic Bcl-2 family members Bak and Bax play central and redundant roles in the regulation of apoptosis. In this study, we investigated the effect of loss of Bax and Bak in the CNS. The adult bax-/-bak-/- mice display masses of densely staining cells in the proliferative zones of the brain. These cells are shown to be a mix of neural progenitor cells and postmitotic cells at different...

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