In the recent years, the role of LOX enzymes in the cause of neoplastic diseases such as colorectal, skin, pancreatic and renal cancers has been confirmed. A new series of 1,3,4-thiadiazole derivatives bearing 2-pyridyl moiety was synthesized and their cytotoxicity was assessed using MTT protocol. Enzyme inhibitory activity of prepared compounds was also tested against 15-lipoxygenase-1 as nove...

This article pursues two tasks. The first is to clarify the value and productivity of Williams’s Keywords: a vocabulary culture society (first edition 1976, second expanded 1983a) for project Cultural Studies. clarification helped, I argue, by reading it alongside Vološinov’s Marxism philosophy language (published in Russian 1929, translated into English 1973). related task speculative developm...