The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influen...

BACKGROUND Tramadol/paracetamol is a fixed-dose combination prescribed for the relief of moderate to severe pain. The combination acts synergistically and guarantees the rapid onset of paracetamol and the prolonged analgesic effect of tramadol with good tolerability. These drugs are often used in various formulations in the treatment of patients with postoperative pain, e.g. after stomach resec...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...

The consistency of a printer to manufacture tablets in uniform and precise fashion is an important element when considering fused deposition modelling. Blends polymer [poly(vinyl alcohol)] drug (paracetamol) different ratios were considered evaluate the mass, content, dissolution performance, thermal properties tablets. Relative standard deviations below 5%, for most study, demonstrated high un...

To my family and To the protectors of human dignity in the city of Kobanê in Rojava and in Bashur. Abstract Oral tablets are convenient and widely administered drug dosage forms. The mechanical properties of a drug substance such as plasticity, ability to cohere into compacts and friction/adhesion are important in the development of a tablet formulation. Crystal engineering is an interesting an...

The study included analysis of five different brands Paracetamol tablets used in market, using the ultra violet spectro-photometric method. percent purity was determined by assay method on uv spectrophotometer. result obtained compared with those standard. Percent content standard IP contain no less than 95.0 and not more 105.0 prescribed value. It noted that samples A, B, D E meet I.P. specifi...

The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimiz...

Accepted 29 March 1996 A 63-year-old woman with longstanding rheumatoid arthritis was receiving warfarin therapy for an aortic valve replacement. The dose of warfarin was monitored via a hospital anticoagulation clinic and remained stable at 4-4.5 mg per day with no significant bleeding or thrombotic episodes. In September 1993 the patient began attending a general-practice-based anticoagulatio...

Adulteration in pharmaceutical products is common all over the world particularly oraldosage forms like tablets, gelatin capsules. According to previous studies there were many techniquesare available recognize counterfeit medicines. Near Infrared Spectroscopic techniques widely usedin this area due its numerous advantages. In work, we used ASD Field Spec4 Spectroradiometerhaving broad spectral...

Hot-melt coating process (HMCP) was applied to develop a lipid based oral controlled release matrix system (tablet) to deliver highly aqueous soluble drugs using paracetamol as a model drug. Granules prepared from paracetamol and particular filler were coated with different levels of lipid and then compressed into tablets to get controlled/sustained delivery of the drug over an optimum period. ...