Antiinflammatory cytokines such as interleukin-10 (IL-10) have been used to modulate and terminate inflammation and provide neuroprotection. Recently, we reported that the modular recombinant transfection vector NLSCt is an efficient tool for transgene overexpression in vivo, which induces neuroprotection as a result of its RGD-mediated integrin-interacting capacity. We here sought to evaluate ...

Ciliary neurotrophic factor (CNTF) is a potent protective factor for striatal neurons in animal models of Huntington's disease (HD). Clinical application of this potential therapeutic still requires the design and optimization of delivery systems. In the case of HD, spatial spread in the vast volume occupied by the striatum and long-term delivery of the factor are particular challenges for thes...

central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

introduction: ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. the aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.methods: in a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (ctee) who admitted to im...

This paper proposes to apply the continuous vector representations of words for discovering keywords from a financial sentiment lexicon. In order to capture more keywords, we also incorporate syntactic information into the Continuous Bag-ofWords (CBOW) model. Experimental results on a task of financial risk prediction using the discovered keywords demonstrate that the proposed approach is good ...