BACKGROUND Macrolide antibiotics, which have anti-inflammatory and immune modulatory effects, have been studied as adjuncts for the management of asthma. However, results have been contradictory and trials underpowered. We therefore sought to conduct a meta-analysis of randomized controlled trials (RCT). METHODS All RCT of prolonged macrolides (3+ weeks) for asthma treatment, published up to ...

Objective(s): Th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. To address this point, the effect of nebulized inhalation of inactivated Mycobacterium phlei on modulation of asthmatic  airway  inflammation was investigated. Materials and Methods: 24 male BALB/c mice were randomly divided into three groups: control group (Group A), asthma model group (G...

BACKGROUND Existing data suggest that obesity correlates with airway hyper-reactivity. However, the incidence of bronchospasm during bariatric surgery in obese patients has not been well studied. METHODS This was a prospective observational study comparing 50 obese versus 50 non obese patients undergoing elective laparoscopic surgery over a 2 year period. Bronchospasm was detected clinically ...

clinical asthma and airway responsiveness appear to be less severe when diabetes is superimposed. the aim of the present study was to determine the possible role of nitric oxide (no) in the airway reactivity under diabetic and diabetic-allergic conditions. twenty-five male guinea-pigs were divided into five groups of five each as follows: diabetic, antigen sensitized, diabetic- antigen sensitiz...

Increased nitric oxide in exhaled gas in patients with asthma is thought to reflect the severity of airway inflammation and perhaps airway reactivity. Several studies attempted to identify a relationship between exhaled NO levels and airway reactivity or severity of airway inflammation for the purpose of finding out if exhaled NO could be used in place of pulmonary function testing and airway p...

There is growing evidence for an association between sensory reactivity and mental health in autism. This study set out to explore the relationship preschool-aged autistic children. In total 54 children with Autism Spectrum Condition took part. Sensory symptoms were obtained from Processing Scale Inventory, Assessment of Neurodevelopmental Differences Behavioral System Children–3. Correlational...

objective(s): th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. to address this point, the effect of nebulized inhalation of inactivated mycobacterium phlei on modulation of asthmatic  airway  inflammation was investigated. materials and methods: 24 male balb/c mice were randomly divided into three groups: control group (group a), asthma model group (g...