Emerging evidence indicates that microRNAs, a class of small and well-conserved noncoding RNAs, participate in many physiological and pathological processes. RNase III endonuclease DICER is one of the key enzymes for microRNA biogenesis. Here, we found that DICER was downregulated in tumor samples of colorectal cancer (CRC) patients at both mRNA and protein levels. Importantly, intestinal epith...

Approaches to data protection have traditionally focused on physical security and/or cryptographic security, but the automatic deletion of data as a form of protection has not been widely employed. However, a vast amount of data is stored that has only a limited useful life and presents a risk to privacy and security after that time period. Approaches to data deletion can be broadly classified ...

** (West Bengal University of Technology, West Bengal, India) *** (West Bengal State University, West Bengal, India) ABSTRACT Key management represents a major and the most sensitive part of cryptographic systems. It includes key generation, key distribution, key storage, and key deletion. It is also considered the hardest part of cryptography. Designing secure cryptographic algorithms is hard,...

Background: Male infertility is a Multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is unknown (idiopathic) and could be congenital or acquired. Globozoospermia, also called round-headed spermatozoa, is a rare disease with incidence< 0.1% among male infertile patients. The most prominent feature of globozoospermi...

Background: Successful IVF process is limited by factors such as oocyte quality. Oocyte quality can be defined as its abilities to be fertilized, mature and give rise to normal offspring and it is dependent on nuclear maturation and cytoplasm maturation. Damage to mitochondrial DNA (mtDNA) has been described in oocytes in IVF failure women that decrease cytoplasmic quality because Mitochondria ...

Deletion from open-address hash table is not so easy as deletion from chained hash table, because in open-address table we can’t simply mark a slot containing deleted key as empty. Search for keys may become incorrect. The classical method to implement deletion is to mark slots in hash table by three values: “free”, “busy”, “deleted”. That method is easy to implement, but there are some disadva...

We present a parallel priority queue that supports the following operations in constant time: parallel insertion of a sequence of elements ordered according to key, parallel decrease key for a sequence of elements ordered according to key, deletion of the minimum key element, and deletion of an arbitrary element. Our data structure is the first to support multi-insertion and multi-decrease key ...

background: spinal muscular atrophy (sma) is the second most common lethal autosomal recessive disease. it is a neuromuscular disorder caused by degenerative of lower motor neurons and occasionally bulbar neurons leading to progressive limb paralysis and muscular atrophy. the smn1 gene is recognized as a sma causing gene while naip has been characterized as a modifying factor for the clinical s...

A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting anti...