Fatty acid b-oxidation occurs in both mitochondria and peroxisomes. Long chain fatty acids are also metabolized by the cytochrome P450 CYP4A v-oxidation enzymes to toxic dicarboxylic acids (DCAs) that serve as substrates for peroxisomal b-oxidation. Synthetic peroxisome proliferators interact with peroxisome proliferator activated receptor a (PPARa) to transcriptionally activate genes that part...

/3-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the condensation reaction of fatty acid synthesis in Escherichia coli. The homogeneous enzyme reacts with hexanoylCoA to form hexanoyl-enzyme which was isolated and characterized. Hexanoyl-enzyme contains 2 mol of hexanoate/mol of enzyme (molecular weight 66,000); it is labile at alkaline pH, and it reacts with neutral hydroxylamine to...

The activity of Rivaroxoban oxazolidinone series against Mycobacterium terrae was investigated in silico and vitro. In studies have shown a high binding affinity Rivaroxaban to β-ketoacyl[ACP]synthase I that plays key role the biosynthesis mycolic acids, being components mycobacterial cell wall. molecular docking study, two main sites with protein were predicted evaluated: minimum energies foun...

4. Biochemistry of palm oil ..................................................................................................................................... 510 4.1. Fruit development and oil deposition ...................................................................................................... 510 4.2. Changes in lipid class and fatty acid composition during development of the o...

An approach for designing bioactive small molecules has been developed in which de novo structure-based ligand design (SBLD) was focused on regions of chemical space accessible using a diversity-oriented synthetic approach. The approach was exploited in the design and synthesis of a focused library of platensimycin analogues in which the complex bridged ring system was replaced with a series of...

Prosthetic lipoyl groups are required for the function of several essential multienzyme complexes, such as pyruvate dehydrogenase (PDH), a-ketoglutarate dehydrogenase (KGDH), and the glycine cleavage system (glycine decarboxylase [GDC]). How these proteins are lipoylated has been extensively studied in prokaryotes and yeast (Saccharomyces cerevisiae), but little is known for plants. We earlier ...