We describe the MR appearance of kernicterus (bilirubin encephalopathy). T2-weighted images show high signal bilaterally in the globus pallidus, a known area of cerebral deposition of bilirubin.

BACKGROUND Kernicterus still occurs around the world; however, the mechanism of bilirubin neurotoxicity remains unclear, and effective treatment strategies are lacking. To solve these problems, several kernicterus (or acute bilirubin encephalopathy) animal models have been established, but these models are difficult and expensive. Therefore, the present study was performed to establish a novel ...

BACKGROUND Blood group mismatch between a mother and newborn carries a substantial risk for neonatal hyperbilirubinemia and kernicterus. In the current study, we investigate the spectrum and outcome of marked neonatal hyperbilirubinemia with blood group incompatibility. METHODS We retrospectively assessed a cohort of 413 neonates with peak total serum bilirubin (TSB) values > or = 20 mg/dL be...

kernicterus (bilirubin induced encephalopathy) is an uncommon disorder with tragic consequences, especially when it affects healthy term and near-term neonates. appointment of cut off value of total serum bilirubin level that have a safe margin for early prompt treatment, as a result, prevention of kernicterus. in our study, all of icteric neonates that admitted in our center in 1 year were enr...

Prediction of diseases would help physicians to make informal decision regarding the type of treatment. Jaundice is the most common condition that requires medical attention in newborn babies. Although most newborns develop some degree of jaundice, a high level bilirubin puts a newborn at risk of bilirubin encephalopathy and kernicterus, which are rare but still occur in Egypt. This paper prese...

B ilirubin can cross the blood-brain barrier, especially when plasma concentrations are high and in neonates. Bilirubin is toxic and can lead to irreversible brain damage, signs of neurologic disease, and coma, which is called “kernicterus.” The most important cause of clinical icterus in equine neonates is neonatal isoerythrolysis (NI), an alloimmune disease characterized by immune-mediated he...