In most eukaryotic cells, the nucleus is localized to a specific location. This highlight article focuses on recent advances describing the mechanisms of nuclear migration and anchorage. Central to nuclear positioning mechanisms is the communication between the nuclear envelope and the cytoskeleton. All three components of the cytoskeleton-microtubules, actin filaments and intermediate filament...

Determining the replication factor y settings S aner et al. describe how neighboring DNA regions stochas-tically assemble into replica-tion factories in budding yeast. A replicon is a stretch of DNA duplicated from a single replication origin. In eukaryotes, multiple replicons assemble into sub-nuclear structures called replication factories, where the replicons are duplicated by DNA polymerase...

Correspondence to Daniel A. Starr: [email protected] Abbreviations used in this paper: DIC, differential interference contrast; fps, frame per second; INM, inner nuclear membrane; KASH, Klarsicht, ANC-1, and Syne homology; LINC, linker of nucleoskeleton and cytoskeleton; NE, nuclear envelope; ONM, outer nuclear membrane; PNS, perinuclear space; SUN, Sad1p and UNC-84; TEM, transmission EM. Int...

in this note we introduce the notion of weak mccoy rings as a generalization of mccoy rings, and investigate their properties. also we show that, if is a semi-commutative ring, then is weak mccoy if and only if is weak mccoy.

Observations stretching back more than two decades have suggested that nuclei and nuclear components are mechanically coupled to the cytoskeleton. In multicellular organisms, this mechanical coupling may extend beyond the plasma membrane to the extracellular matrix and adjacent cells. More recently, studies on a variety of human diseases associated with defects in nuclear envelope (NE) proteins...

Regulation of nuclear movement is a critical event in neurogenesis and neuronal migration during brain development. In this issue of Neuron, Zhang et al. identify a role for SUN and the KASH-domain-containing nuclear membrane proteins as the long-sought linker between microtubules and the nucleus during brain development.