The endogenous reactive oxygen species ("ROS") formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for "ROS" formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanth...

The endogenous reactive oxygen species ("ROS") formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for "ROS" formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanth...

The most marked chemical changes in a disintegrating spleen are noticed during the period when karyorrhexis and karyolysis are the characteristic features. When pyknosis alone is prominent almost all of the several constituents are in the coagulable or precipitable fraction, just as they are in the original normal tissue. After karyolysis is practically complete the coagulable and precipitable ...

in this research, we investigated the cytotoxic mechanisms of cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.this micro algae is responsible for a severe and widespread harmful algal bloom in the persian gulf and gulf of oman (2008-2009). isolated hepatocytes were obtained by collagenase perfusion of sprague-dawley rat liver.according to our results, incubation of algal...

it has already been reported that muscle necrosis induced by various phenylenediamine derivatives are correlated with their autoxidation rate. now in a more detailed investigation of the cytotoxic mechanism using a model system of isolated hepatocytes and ring-methylated structural isomer durenediamine (dd) we have shown that under aerobic conditions, phenylenediamine induced cytotoxicity and r...

Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively at basolateral side hepatocytes, mediates uptake conjugated In conditions where flow is impaired (cholestasis), pharmacological inhibition NTCP-mediated acid influx suggested to reduce hepato...

Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. Therefore, the objective of this study was to analyze correlation between sociocult...

background: the alcoholic decoction of root ethanolic extract of aristolochia ringens is taken orally to treat various ailments in south-west nigeria without prior knowledge of its potential toxic effect. therefore, this study aimed at assessing the toxicity potentials of root ethanolic extract of a. ringens on functional indices and histology of the liver. methods: twenty male rats were random...

chemokines are classified in four distinct groups as cxc, cc, cx3c and c, depending on the presence or absence of a motif called elr (arg-leu-glu) before the first cysteine residue in their structure. cxc chemokines are also subdivided into elr + and elr - . increasing evidence has indicated the existence of a chemokine network in the liver which is involved in both physiological responses and,...