The norm convergence of the Trotter{Kato product formula is established with ultimate optimal error bound for the self-adjoint semigroup generated by the operator sum of two self-adjoint operators. A generalization is also given to the operator sum of several self-adjoint operators.

IZUMIYAMA, T., HIDA, W., ICHINOSE, M., INOUE, H., TAKISHIMA, T., OKAZAKI, T. and SHIRATO, K. Small Airway Involvement in Mixed Connective Tissue Disease. Tohoku J. Exp. Med., 1993, 170 (4), 273-283 We studied pulmonary functions in 17 female patients with mixed connective tissue disease (MCTD) to detect early pulmonary involvement in this disease; in 8 of the 17 patients followup studies were a...

NISHIMURA, Y., HIDA, W., TAGUCHI, 0., SAKURAI, M., ICHINOSE, M., INOUE, H. and TAKISHIMA, T. Respiratory Muscle Strength and Gas Exchange in Neuromuscular Diseases : Comparison with Chronic Pulmonary Emphysema and Idiopathic Pulmonary Fibrosis. Tohoku J. Exp. Med., 1989, 159 (1), 57-68 To examine whether or not the respiratory muscle weakness is correlated with decrease in arterial oxygen tensi...

The Edmonston strain of measles virus (MV) that utilizes the human CD46 as the cellular receptor produced cytopathic effects (CPE) in all of the primate cell lines examined. In contrast, the wild-type MV strains isolated in a marmoset B-cell line B95a (the KA and Ichinose strains) replicated and produced CPE in some but not all of the primate lymphoid cell lines. To determine the mechanism unde...

The Kaluza-Klein theory and Randall-Sundrum theory are examined comparatively, with focus on the behavior of the five dimensional (Dirac) fermion in the dimensional reduction to four dimensions. They are properly treated using the Cartan formalism. In the KK case, the dual property between the electric and magnetic dipole moments is revealed in relation to the ratio of two massive parameters: t...

2005;352:1967–76. 9 Ito K, Lim S, Caramori G, et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002;99:8921–6. 10 Cosio BG, Tsaprouni L, Ito K, et al. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004;200:689–95. 11 Ito K, Y...

Purpose: Detection of the intersegmental line during thoracoscopic segmentectomy is sometimes difficult. We describe a newly evolved technology using indocyanine green (ICG)-fluorescence navigation during this procedure. Description: We performed thoracoscopic right segments 8 and 9 anatomical segmentectomy on a 48-year-old man with pulmonary metastasis of osteosarcoma. Preoperative three-dimen...

Biotic stresses are major constraints limiting the leaf quality and productivity of mulberry. MLX56 is a unique chitin-binding protein isolated from Shin-Ichinose (Morus alba) latex that displays toxicity against lepidopteran caterpillars. In this study, the full-length cDNA encoding MLX56 was isolated from Husang 32 (M. multicaulis) and designated HMLX56. Amino acid sequence analysis and prote...

27-Hydroxycholesterol accelerates cellular senescence in human lung 1 resident cells 2 3 Yuichiro Hashimoto, Hisatoshi Sugiura, M.D., Ph.D., Shinsaku Togo, M.D., Ph.D., Akira 4 Koarai, M.D., Ph.D., Kyoko Abe, M.D., Ph.D., Mitsuhiro Yamada, M.D., Ph.D., Tomohiro 5 Ichikawa, M.D., Ph.D., Takashi Kikuchi, M.D., Ph.D., Tadahisa Numakura, M.D., 6 Katsuhiro Onodera, M.D., Rie Tanaka, M.D., Kei Sato, ...

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the mitochondria of testis and spermatozoa. We previously found a significant decrease in the expression of GPx4 in spermatozoa from 30% of infertile human males diagnosed with oligoasthenozoospermia (Imai, H., Suzuki, K.,...