Abstract. Under a markovian evolutionary process, the expected number of substitutions per site (also called branch length) that have occurred when a sequence has evolved from another according to a transition matrix P can be approximated by − 1 4 log detP. When the Markov process is assumed to be continuous in time, i.e. P = expQt it is easy to simulate this evolutionary process for a given br...

The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly due to the presence of hypoxic regions, which are frequently found in GBM tumors. We investigated the radiosensitizing effects of MEK/ERK inhibition on GBM cell lines under hypoxic conditions. Four human GBM cell lines, ...

YhdE is a Maf-like (multicopy associated filamentation) protein that primarily acts as dTTPase to hydrolyze dTTP into dTMP and two phosphate molecules in cell metabolism pathway. Two crystal structures of YhdE have been previously determined, representing the open and closed active site conformations, respectively. Based on the structures, we have carried out molecular dynamics simulations and ...

Matrix multiplication (MM) is one of the core problems in the high performance computing domain and its efficiency impacts performances of almost all matrix problems. The high-density multi-GPU architecture escalates the complexities of such classical problem, though it greatly exceeds the capacities of previous homogeneous multicore architectures. In order to fully exploit the potential of suc...

BACKGROUND Extra-intestinal pathogenic E. coli (ExPEC), including Avian Pathogenic E. coli (APEC), are very diverse. They cause a complex of diseases in Human, animals, and birds. Even though large plasmids are often associated with the virulence of ExPEC, their characterization is still in its infancy. METHODOLOGY/PRINCIPAL FINDINGS We fully sequenced and analyzed the large plasmid pAPEC-1 (...

We present a multi-GPU design, implementation and performance evaluation of the Halevi-Polyakov-Shoup (HPS) variant Fan-Vercauteren (FV) levelled Fully Homomorphic Encryption (FHE) scheme. Our design follows data parallelism approach uses partitioning methods to distribute workload in FV primitives evenly across available GPUs. The is put address space runtime requirements FHE computations. It ...

A recombinant clone encoding enzymes for Klebsiella pneumoniae O12-antigen lipopolysaccharide (LPS) was found when we screened for serum resistance of a cosmid-based genomic library of K. pneumoniae KT776 (O12:K80) introduced into Escherichia coli DH5alpha. A total of eight open reading frames (ORFs) (wb(O12) gene cluster) were necessary to produce K. pneumoniae O12-antigen LPS in E. coli K-12....

A total of 121 E. coli strains were isolated from broiler chickens (96 extraintestinal pathogenic (ExPEC) strains from diseased broiler chickens and 25 avian fecal E. coli (AFEC) from healthy ones). Ten of the isolates (6 from diseased chickens and 4 from healthy birds) were serogrouped and 25 were examined for 4 virulence markers (tsh, papC, colV, and iss genes) as well as for their antimicrob...

This study was designed to determine the isolation rate, serovars and biochemical profiles of e. coli from cases of colibacillosis and dead-in-shell embryos in Zaria-Northern Nigeria. The isolation rate of e. coli from hatcheries studied were 4.67% and 7.50% from farms of Simtu Agricultural Company and National Animal Production Research Institute (NAPRI) Shika Zaria, Nigeria respectively. Twen...

Uropathogenic Escherichia coli are the major causative agent of urinary tract infection--they may simultaneously express a number of virulence factors to cause disease. The aim of this study was to investigate the relation between virulence factors content of fifteen UPEC isolates and their pathogenic potential. The isolates belonged to the five serotypes O78:K80, O114:K90, O142:K86, O164 and O...