CONTEXT
Kisspeptin and neurokinin B (NKB) are obligate for normal gonadotropin secretion, but their hierarchy is unexplored in normal women.
OBJECTIVE
To investigate the interaction between kisspeptin and NKB on estrogen-regulated LH secretion.
DESIGN
Women were treated with neurokinin-3 receptor (NK3R) antagonist followed by transdermal estradiol to induce LH secretion 48 hours later, with...
