Aggressive periodontitis is characterized by rapid attachment and bone loss with no underlying systemic disease and is associated with specific bacteria like Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg). In this case series 25 patients were diagnosed with aggressive periodontitis by the aid of DNA probes for Aa and Pg and other periodontal pathogens. The use of DN...

Background: The menopausal transition called perimenopause, happens after the reproductive years, and isspecified with irregular menstrual cycles, perimenopause symptoms and hormonal changes. Women going throughperi menopausal period are vulnerable to bone loss.Osteoporosis is one of the most common debilitating metabolic bone diseases ,especially in the women almostaround 50 years .This study ...

BACKGROUND Caffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects. METHODS To examine the association between the cumulative dose and duration of therapy of caffeine and osteopenia of prematurity, a retrospective cohort study was conducted including premature infants less than 31 weeks and birth weight less than 1500 g. Osteope...

OBJECTIVE The aim of the study was to investigate bone mineral density (BMD) in young Saudi females (20-25 years) using Dual-energy x-ray absorptiometry (DXA), as it is a widely utilized modality for the measurement of BMD, used for the diagnosis of osteoporosis and osteopenia. METHODS BMD measurements were performed in the spine and the neck of the femur in 101 young females. RESULTS 37% a...

BACKGROUND Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis. METHODS We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women w...

BACKGROUND AND OBJECTIVE An early detection of osteoporosis through DEXA procedure will not only improve the disease management practices but also would help in impeding national productivity losses by mass screening and awareness. Our objective was to measure efficacy of DEXA procedure in early detection of osteoporosis and prevention of its complications. METHODS This case series observatio...

Osteoporosis is the most common metabolic bone disease; it is an important health problem among postmenopausal women. We evaluated the association of three polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density (BMD) serum TGF-β1 levels in 278 postmenopausal female osteopenia/osteoporosis subjects and 95 postmenopausal female control subjects. Serum TGF-β1 le...

The majority of women with fragility fractures have osteopenia rather than osteoporosis. In post hoc analyses of trials of alendronate and strontium ranelate, women with osteopenia had significant reductions in the incidence of fragility fractures and specific therapies may be mandated in women with osteopenia, as well as those with osteoporosis. Increasing numbers of fractures of the spine and...

Del(22q11) is a common microdeletion syndrome with an extremely variable phenotype. Besides classical manifestations, such as velocardiofacial (Shprintzen) or DiGeorge syndromes, del(22q11) syndrome may be associated with unusual but probably causally related anomalies that expand its phenotype and complicate its recognition. We report here three children with the deletion and a chronic, erosiv...

Background: Juvenile idiopathic arthritis (JIA) is the most common type of in childhood (1). Prompt diagnosis mandatory to avoid joint destruction and growth abnormalities. However, it’s often misdiagnosed by pediatricians general practitioners leading longer delay (2). Objectives: The aim this study was evaluate lag time between JIA symptoms onset its impact on disease activity bone loss. Meth...