Autism is a developmental disorder characterized by pervasive social and communication impairments and restricted range of interests and activities. Although the specific cause is unknown, proposed etiologies for autism have included autoimmune dysregulation of cellular or humoral components and maternal–fetal immunoregulation problems. Juvenile rheumatoid arthritis (JRA) constitutes several he...

OBJECTIVE To investigate the association between CD5+ B cell expression and IgM rheumatoid factor (IgM-RF) in juvenile rheumatoid arthritis (JRA). METHODS CD5+ B cell levels analyzed by flow cytometry and IgM-RF expression determined by enzyme-linked immunosorbent assay were compared in children with JRA, children with other collagen vascular diseases, and healthy controls. RESULTS Children...

OBJECTIVES To distinguish the effects of juvenile rheumatoid arthritis (JRA) on bone mineralisation from those possibly caused by steroid therapy. METHODS Bone mineral status was evaluated in 20 children (five boys and 15 girls) with active JRA who never received steroids. Seven had oligoarticular, nine had polyarticular, and four had systemic JRA. Bone mineral content (BMC) was assessed by s...

In many high altitude river basins, the hydro-climatic regimes and spatial temporal distribution of precipitation are little known, complicating efforts to quantify current future water availability. Scarce, or non-existent, gauged observations at altitudes coupled with complex weather systems orographic effects further prevent a realistic comprehensive assessment precipitation. Quantifying con...

Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that suggest equally important contributions of the innate immune system. We used gene expression arrays and computer modeling to examine the function in neutrophils of 25 children with polyarti...

Abstract. This study quantifies differences among four widely used atmospheric reanalysis datasets (ERA5, JRA-55, MERRA-2, and CFSR) in their representation of the dynamical changes induced by springtime polar stratospheric ozone depletion Southern Hemisphere from 1980 to 2001. The intercomparison is undertaken as part SPARC (Stratosphere–troposphere Processes Role Climate) Reanalysis Intercomp...

OBJECTIVE To assess social functioning and facial expression recognition skill in survivors of pediatric brain tumors (BT) as compared to children with juvenile rheumatoid arthritis (JRA). METHODS The social functioning of 51 survivors of BT and 31 children with JRA was assessed using a facial expression recognition task, questionnaire ratings of social functioning, and an IQ screener. RESU...

Parents of 135 children with juvenile rheumatoid arthritis (JRA) completed a mailed questionnaire about problems at school. Writing was the most frequently reported difficulty, with hand involvement causing more problems than decreased mobility. Compared to children with pauciarticular JRA, those with polyarticular or systemic JRA were significantly more likely to miss school, experience proble...