The Rockefeller University Press $30.00 J. Exp. Med. 2016 Vol. 213 No. 4 467–468 www.jem.org/cgi/doi/10.1084/jem.20160211 467 Since its inception in 1896, The Journal of Experimental Medicine (JEM) has aimed to publish outstanding and enduring studies in medical biology, with an emphasis on pathogenesis (Welch, 1896). The founding editors and their successors have strived to provide a prestigio...

We present an update to an electric shock job exposure matrix (JEM) that assigned ordinal electric shocks exposure for 501 occupational titles based on electric shocks and electrocutions from two available data sources and expert judgment. Using formal expert elicitation and starting with data on electric injury, we arrive at a consensus-based JEM. In our new JEM, we quantify exposures by addin...

OBJECTIVES To construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments. METHODS Departmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data we...

We outline methods for integrating epidemiologic and industrial hygiene data systems for the purpose of exposure estimation, exposure surveillance, worker notification, and occupational medicine practice. We present examples of these methods from our work at the Rocky Flats Plant--a former nuclear weapons facility that fabricated plutonium triggers for nuclear weapons and is now being decontami...

In this issue of JEM, Marciniak et al. (https ://doi .org /10 .1084 /jem .20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer’s disease, impairment of brain insulin signaling might occur via tau loss of ...

In this issue of JEM, Deniset et al. (https://doi.org/10.1084/jem.20161621) provide new data that extend our knowledge on the mechanisms whereby Streptococcus pneumoniae is cleared by the spleen. The authors identify novel populations of murine splenic neutrophils that localize in the red pulp and the marginal zone. During the acute phases of S. pneumoniae infection, these populations of spleni...

In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti-PD-1 blo...

We are excited to introduce a new design for JEM.

We live in a scientific universe in which subject boundaries are increasingly porous. Department definitions in many institutions are either close to meaningless or nonexistent, and many faculty count themselves as active participants in at least two, if not more, of the major disciplines of biology. Thus, it is with great pleasure that we announce a new cross-listing project for the JEM and th...