Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy over conventional treatments alone. In this study, a fully human anti-IGF-IR mono...

Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy over conventional treatments alone. In this study, a fully human anti–IGF-IR mono...

We report the observation of spin segregation, i.e., time-dependent separation of the spin density profiles of two spin states, in a trapped, coherently prepared Fermi gas of 6Li with a magnetically tunable scattering length a12 close to zero. For |a12| approximately = 5 bohr, as the cloud profiles evolve, the measured difference in the densities at the cloud center increases in 200 ms from 0 t...

We prove that if A ⊂ Fq\{0} with |A| > Cq 5 6 , then |R(A) ·R(A)| ≥ C′q3, where R(A) = {( a11 a12 a21 a22 ) ∈ SL2(Fq) : a11, a12, a21 ∈ A } . The proof relies on a result, previously established by D. Hart and the author ([3]) which implies that if |A| is much larger than q 3 4 then |{(a11, a12, a21, a22) ∈ A×A×A×A : a11a22 − a12a21 = 1}| = |A|4q−1(1 + o(1)).

ADAM 17 (TNF-α converting enzyme, TACE) is a potential target for cancer therapy, but the small molecule inhibitors reported to date are not specific to this ADAM family member. This membrane-bound metalloproteinase is responsible for ectodomain shedding of pathologically significant substrates including TNF-α and EGFR ligands. The aim of this study was to evaluate the pharmacokinetics, pharmac...

One Muslim is Enough!” Evidence from a Field Experiment in France Anti-Muslim prejudice is widespread in Western countries. Yet, Muslims are expected to constitute a growing share of the total population in Western countries over the next decades. This paper predicts that this demographic trend will increase anti-Muslim prejudice. Relying on experimental games and a formal model, we show that t...

The Net Present Value maximizing model has a respectable ancestry and is considered by most scholars a theoretically sound decision model. In real-life applications, decision makers use the NPV rule, but apply a subjectively determined hurdle rate, as opposed to the “correct” opportunity cost of capital. According to a heuristics-and-biases-program approach, this implies that the hurdle-rate ru...

This paper analyses both, the physical concept of Energy and its applications, from point view Human Action, or Praxeology. In this task, author applies analytical toolbox developed by Austrian School Economics. order to make analysis comprehensible, first develops an Ontological Scientific perspective, then offers a brief history utilisation human being achieve his goals. Once established depa...

Graduate economic programmes in Latin America have evolved along the lines of two different traditions: one closely linked to the current economic mainstream (being in that sense ‘global’) and the other more local and heterodox. This paper provides an overview of perceptions, interests, concerns and opinions of global Latin American graduate economic programmes, comparing them with similar prog...