نتایج جستجو برای: japanese spitz
تعداد نتایج: 86332 فیلتر نتایج به سال:
© 2014 The Authors. doi: 10.2340/00015555-1641 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Spitz naevus was first described by Sophie Spitz in 1948 (1). It is a variant of benign melanocytic naevus composed of spindled and epithelioid melanocytes, found predominantly in children and adolescents. A number of histopathological variants have been reported, such as desmopl...
Pigmented Spitz nevus is a benign melanocytic skin lesion with distinct clinical features and it is frequently found on the extremities. However, it rarely occurs on acral area of the body, and such a case has not yet been fully documented. We present a case of acral pigmented Spitz nevus occurring on the foot, and this mimicked acral lentiginous malignant melanoma. Clinicians should be well aw...
The plaque-type blue nevus (PTBN) is a rare variant of blue nevus, of which only a few reports are described. A nodular growth within a preexistent PTBN should always alert to the possibility of malignant transformation. The authors report the first case of an atypical Spitz tumor arising on a congenital linear PTBN in a 60-year-old woman. The diagnosis of "atypical Spitz tumor" is here used to...
Plantar melanoma Superficial spreading melanoma Spitz nevus Dr. Taizo Kato, Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 98077 (Japan) The acral regions of the limbs are the commonest site for melanoma in the Japanese [1, 2]. This high proportion of acral melanoma may be the result of the relatively low occurrence of melanoma in other parts of...
Activation of the Drosophila EGF receptor requires the transmembrane TGF-alpha-like ligand Spitz. Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz.
Epidermal growth factor receptor (EGFR) ligands undergo a complex series of processing events during their maturation to active signaling proteins. Like its mammalian homologs, the predominant Drosophila EGFR ligand Spitz is produced as a transmembrane pro-protein. In the secretory pathway, Spitz is cleaved within its transmembrane domain to release the extracellular signaling domain. This doma...
BACKGROUND The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS Digitalized images of skin lesions from 679 patients with histopathological dia...
The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Until now, the mechanism of this key signaling regulator has been obscure, but our analysis suggests that Rhomboid-1 is a novel intramembrane serine protease that directly cleaves Spitz. In accordance with the putative R...
Spitz nevus is a benign melanocytic lesion and also one of the main differential diagnosis of melanoma. A descriptive and retrospective study of surgical specimens from patients with a diagnosis of Spitz nevus was conducted at two institutions in Niterói - RJ. 32 cases were analyzed. The most frequent histological subtype was compound (60 %), with a predominance of epithelioid cells (17 cases -...
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