Review methods MEDLINE, EMBASE/Excerpta Medica, Cochrane Library, Scopus, CINAHL, ClinicalTrials.gov (all to Nov 2012); and reference lists were searched for randomized controlled trials (RCTs). 50 RCTs (n = 294 478, mean age 49 to 82 y), including 45 double-blind, placebo-controlled trials and 5 open-label, controlled trials, met the selection criteria. 30 RCTs were done in primary prevention ...

Studies were identified on internet by searching on address: http://www.ncbi.nlm.nih.gov/pubmed/ with criteria that studies should be placebo-controlled and randomized in trials of alpha-blockers in chronic category III prostatitis evaluated by symptom-score NIH-CPSI. From 13 clinical studies three were excluded because of not using NIH-CPSI, three were in Chinese language and two were congress...

This study aims to determine whether bisphosphonates are safe, as well as effective against bone mineral loss in inflammatory bowel disease (IBD). A computerized search of electronic databases from 1966 to 2016 was performed. Randomized controlled trials (RCTs) were included in this review to evaluate the role of bisphosphonates in the management of osteoporosis in IBD patients. A revised 7-poi...

BACKGROUND Due to safety concerns and side effects of many antidepressant medications, herbal psychopharmacology research has increased, and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder (MDD). Of these, accumulating trials reveal positive effects of the spice saffron (Crocus sativus L.) for the treatme...

The Internet and evidence-based decision-making: a needed synergy for efficient knowledge management in health care Alex Jadad Health Information Unit, McMaster University, Canada

OBJECTIVE To conduct a systematic review on the safety of ranibizumab injections for diabetic macular edema by meta-analysis of recently conducted level 1 randomized clinical trials. DESIGN A meta-analysis and systematic review. METHODS Main outcome measures of permissible studies were extracted and reported. The relative risk (RR) for thromboembolic events (TEEs) was calculated for those s...

M e t h o d s Data sources: PubMed, EMBASE/Excerpta Medica, Science Citation Index, and Chinese Biomedical Database (all to October 2006); Cochrane Controlled Trials Register (Issue 2, 2006); reference lists of retrieved articles; abstracts of major gastroenterological meetings; and authors in the field. Study selection and assessment: Randomized controlled trials (RCTs) published in English or...

To assess the effects of medicinal plants (MPs) or related natural products (RNPs) on fibromyalgia (FM) patients, we evaluate the possible benefits and advantages of MP or RNP for the treatment of FM based on eight randomized placebo-controlled trials (RCTs) involving 475 patients. The methodological quality of all studies included was determined according to JADAD and "Risk of Bias" with the c...

Purposes: To review the current literature on pain management in fibromyalgia (FMS) including complementary alternative medicine (CAM) use and to report on treatment and rehabilitation strategies. Methods: A literature review of MEDLINE and EMBASE for published randomized controlled trials for FMS pain treatment was carried out. This was critiqued with the Jadad criteria for quality trials in t...