血管内大細胞型B細胞リンパ腫（IVLBCL）はリンパ腫が血管内に増殖する疾患であり，貧血や低アルブミン血症，血清乳酸脱水素酵素の上昇などを呈する．今回我々は，脳梗塞がこれらの症状に先行し，診断に難渋したIVLBCLを経験した．症例は65歳男性．ふらつきで受診し，頭部MRIで多発脳梗塞を認めた．経食道心エコーで左心耳内血栓を認め，心原性脳塞栓症として治療するも，脳梗塞を繰り返した．経過中に微熱が出現し，貧血と低アルブミン血症，血清乳酸脱水素酵素，可溶性IL-2受容体の上昇を認めた．ランダム皮膚生検で，IVLBCLと診断した．化学療法を施行したが，3年後に死亡した．本例は左心耳内血栓を合併し，全身症状が出現するまで心原性脳塞栓症との鑑別が困難だった．抗凝固療法中にもかかわらず，短期間に脳梗塞を繰り返す場合には，IVLBCLも念頭に置く必要がある．

Intravascular large B-cell lymphoma (IVLBCL) is a very rare extra nodal lymphoma that tends to proliferate within small blood vessels, particularly capillaries and postcapillary venules while sparing the organ parenchyma. The cause of its affinity for the vascular bed remains unknown. Because of its rarity and unremarkable clinical presentation, a timely diagnosis of IVLBCL is very challenging....

Intravascular large B-cell lymphoma (IVLBCL), which involves the lumen of small vessels, is a rare variant of extranodal diffuse large B-cell lymphomas. Herein, we present a case of IVLBCL manifesting as cholecystitis in a 77-year-old Japanese man. He presented with fever, fatigue, and weight loss. Physical examination revealed tenderness of the right upper quadrant. The white blood cell count ...

Abstract Introduction/Objective Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive defined by the proliferation of atypical cells in lumen all sized blood vessels, particularly capillaries. The reasons for this unusual neoplastic cell are still only partially understood. IVLBCL considered stage IV and manifests with variety nonspecific signs symptoms. Patients usually...

Chromosomal abnormalities of intravascular large B-cell lymphoma (IVLBCL), a rare form of extranodal diffuse large B-cell lymphoma, have been described in only a small number of cases. A 59-year-old female presented with pancytopenia and splenomegaly. Bone marrow was normocellular with 30.4% abnormal large lymphoid cells that were positive for CD5, CD19, CD20, HLA-DR and λ chain. Bone marrow bi...

A 58-year-old woman was admitted with refractory fever despite receiving broad-spectrum antibiotics. She had hypoxemia, severe anemia, elevated levels of serum lactic dehydrogenase and soluble interleukin-2 receptor, and a positive direct Coombs test, which suggested an underlying autoimmune hemolytic anemia (AIHA). Chest computed tomography (CT) showed no abnormal findings, but she had hypoxia...

Case Presentation. A 69-year-old Hispanic male, with a past history of diabetes and coronary disease, was admitted for fever, diarrhea, and confusion of 4 weeks duration. Physical examination showed a disoriented patient with multiple ecchymoses, possible ascites, and bilateral scrotal swelling. Hemoglobin was 6.7, prothrombin time (PT) 21.4 seconds with international normalized ratio 2.1, part...

Introduction: Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive for which there no available standard treatment. IVLBCL characterized by selective growth in the lumina of small vessels systemic organs usually presents with many nonspecific signs and symptoms such as fever unknown origin involvement central nervous system skin. Methods: This retrospective, single-cent...