This study aims to investigate whether personalized embryo transfer (pET) guided by endometrial receptivity analysis (ERA) improves the clinical pregnancy rate for non-recurrent implantation failure (non-RIF) in vitro fertilization (IVF) patients Chinese population. is a single-center, retrospective cohort of with 0-2 previous failed implantations following high-quality at Chengdu Jinjiang Dist...

Aspects of the immunological relationship between mother and conceptus still remain a mystery, although the recent advances in molecular biology have enlightened some of the parameters that participate in feto-maternal cross-talk during implantation. The atypical expression of major histocompatibility complex (MHC), the specific roles of some hormones and cytokines, as well as the temporal and ...

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background: infertility is an increasing medical and social problem. in vitro fertilization (ivf) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. natural killer (nk) cells have been identified as relevant immunological factors involved in reproductive success or failure. objective: the aim of this study was to compare the percentage of...

Background: In spite of the great deal of research in assisted reproductive techniques, more than 80% of transferred embryos by IVF/ICSI methods fail to be implanted. The causes for repeated implantation failures (RIF) may be reduced endometrial receptivity or other various uterine pathologies, such as thin endometrium, altered expression of adhesive molecules or immunological factors; whereas ...

BACKGROUND It is generally acknowledged that the outcomes of IVF treatments are correlated between repeat cycles in the same couple and that these effects need to be allowed for in the analysis of such treatments. However, there are few studies that have attempted to estimate the magnitude of these effects or their clinical consequences. METHODS We use the embryo-uterus model, extended to inc...

Trophectoderm cell lines were established from 8-day in vitro-cultured embryos of cattle derived from fertilization (IVF), somatic cell nuclear transfer (NT), or parthenogenetic activation (P) of in vitro-matured oocytes and from five 8-day-old in vivo (V) embryos. The most abundant cellular proteins of 5 V-, 16 NT-, 12 P-, and 16 IVF-derived cell lines were compared by 2D-gel electrophoresis a...

BACKGROUND There are few effective approaches to infertile patients with repeated failure in IVF-embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear cells (PBMCs). METHODS Patients who had not experienced successful pregnancy despite fo...

The purpose of this study was to investigate whether sperm selection by hyaluronic acid (HA) binding could improve fertilization rate and embryo quality in intracytoplasmic sperm injection (ICSI) cycles. Two hundred nineteen oocytes obtained from eighteen women were injected with either HA-bound (n = 107) or conventionally selected spermatozoa (n = 112) in a randomized way. All of the participa...

OBJECTIVE To evaluate the effects of vaginally administered sildenafil on endometrial thickness and IVF outcome in a large cohort of infertile women with poor endometrial development. DESIGN Retrospective cohort analysis. SETTING Private practice setting. PATIENT(S) A cohort of 105 infertile women aged <40 years, with normal ovarian reserve and at least two consecutive prior IVF failures ...