Tramadol is one of the most widely used centrally acting analgesics worldwide. Because of its multimodal analgesic mechanism (opioid plus nonopioid), the adverse effects profile of tramadol, similar to its analgesic profile, can be atypical compared with single-mechanism opioid analgesics. The comparison is often favorable (e.g., less respiratory depression or abuse), but it is sometimes cited ...

conclusions the addition of tramadol to epidural 2% lidocaine offers advantages in cesarean section. results in the lt100 group, onset of complete sensory and motor blockade at t6 was less than in the two other groups, but the highest level of sensory blockade and two segment regression and duration of motor blockades between the lt50 and lt100 groups were not significantly different, although ...

The metabolism of cis-tramadol has been studied in human liver microsomes and in cDNA-expressed human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the NADPH-dependent metabolism of tramadol to the two primary tramadol metabolites, namely, O-desmethyl-tramadol (metabolite M1) and N-desmethyl-tramadol (metabolite M2). In addition, tramadol was also metabolized to two minor se...

Tramadol, a centrally acting analgesic, consists of two enantiomers, both of which contribute to analgesic activity via different mechanisms. (+) Tramadol and the metabolite (+) -Odesmethyl-tramadol (M1) are agonists of the mu opioid receptor. (+) Tramadol also stimulates presinaptic release of serotonin and inhibits serotonin reuptake weheres (-) tramadol inhibits norepinephrine reuptake. Thus...

Tramadol is a centrally acting opioid analgesic which is mainly used for the treatment of moderate to severe pain [2]. Its efficiency and potency ranges between weak opioids and morphine [3]. Tramadol is rapidly absorbed orally; Tramadol has extensive tissue distribution. The bioavailability of tramadol is 70 % its bioavailability is more than that of morphine (1565%) when tramadol is used in m...

BACKGROUND Opioid analgesics are commonly added to epidural local anesthetics to improve analgesia during surgery. OBJECTIVES The goal of this study was to evaluate the maternal and neonatal effects of adding different doses of tramadol to 2% lidocaine in the epidural anesthesia for cesarean section. PATIENTS AND METHODS Ninety pregnant patients who were candidates for cesarean section unde...

OBJECTIVES The aim of this study was to investigate whether tramadol had a dose-dependent blocking effect on nerve conduction when administered perineurally to the sural nerve of healthy volunteers. METHODS Twenty-four informed healthy subjects were randomized into four equal groups [Saline (placebo), 0.5% tramadol, 1% tramadol and 1.5% tramadol]. The study was designed to be double-blinded. ...

BACKGROUND AND GOAL OF STUDY After laparoscopic cholecystectomy, patients have moderate pain in the early postoperative period. Some studies shown beneficial effects of subcostal transversus abdominis plane block on reducing this pain. Our goal was to investigate influence of subcostal transversus abdominis plane block on postoperative pain scores and opioid consumption. MATERIALS AND METHODS...

BACKGROUND Tramadol is a centrally acting analgesic, whose mechanism of action involves opioid-receptor activation. Previously, we have shown that tramadol and its enantiomers had a negative inotropic effect on the papillary muscle in which the (+)-enantiomer is more potent than (-)- and (±)-tramadol. OBJECTIVE In this study, we investigated the effects of tramadol and its enantiomers on L-ty...

Background: Seizure is one of the possible adverse effects of tramadol hydrochloride, a synthetic, centrallyacting analgesic, prescribed for the treatment of moderate to severe pain. In this study, we describe 106 patients with tramadol induced seizures. Methods: The patients, who were referred to Nemazee Hospital, Shiraz, Iran, from March 2006 to March 2008, were examined in this cross-section...