A nursery outbreak of fever and clinical sepsis resulted in the deaths of 36 neonates in Roraima, Brazil. To determine the cause, epidemiologic studies were performed, along with culture and endotoxin analysis of intravenous (iv) fluids. Affected neonates were more likely to have lower birth weight (2.1 vs. 3.2 kg; P<.01), lower APGAR (activity, pulse, grimace, appearance, and respiration) scor...

Pulse IV methylprednisolone therapy is the intermittent administration of supraphysiological quantities of the drug to enhance its therapeutic effects while reducing its toxic effects.1 A typical pulse regimen ranges from 500 to 1000 mg IV daily for 2–4 consecutive days.1,2 It has been suggested that methylprednisolone may cause an acute increase in serum creatinine (SCr), which can be misinter...

We tested the hypothesis that increased pulse wave reflection and altered backward waveform morphology contribute to increased pulse pressure in subjects with higher pulse pressure compared with lower pulse pressure and to actions of vasoactive drugs to increase pulse pressure. We examined the relationship of backward to forward wave morphology in 158 subjects who were evaluated for hypertensio...

arterial pulse measurement is one of the most important methods for evaluation of healthy conditions. in traditional iranian medicine (tim), physician may detect radial pulse by holding four fingers on the patient’s wrist. by using this method, under standard condition, the detected pulses are subjective and erroneous, in case of weak and/or abnormal pulses, the ambiguity of diagnosis may rise....

OBJECTIVES The study sought to assess feasibility, safety, and potential efficacy of a novel implantable extra-aortic counterpulsation system (C-Pulse) in functional class III and ambulatory functional class IV heart failure (HF) patients. BACKGROUND 30% to 40% of HF patients suffer from poor functional status and quality of life (QoL) but are not in need of end-stage treatments. We undertook...

PURPOSE To determine the distribution of the protease IV gene, the production of this and other proteases by multiple strains of Pseudomonas, and the virulence of a mutant specifically deficient in protease IV. METHODS The protease IV gene was cloned, its sequence analyzed, and its chromosomal location determined by pulse-field gel electrophoresis. Three PCR reactions were used to detect the ...

The relevance of cortical grey matter pathology in multiple sclerosis has become increasingly recognised over the past decade. Unfortunately, a large part of cortical lesions remain undetected on MRI using standard field strength. In vivo studies have shown improved detection by using higher magnetic field strengths up to 7 T. So far, a systematic histopathological verification of ultrahigh-fie...

On physical exam her vital signs are blood pressure 120/80, pulse 68, respiratory rate 14, temperature 98, pulse oximetry 98% saturated. She is alert, oriented to person, place, and time; she can recite the months of the year forward and backwards, has 3 object recall after 5 minutes. Cranial nerves II, III, IV, and VI are intact including a normal appearing fundus with venous pulsations. There...

Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurate mouse model of mucolipidosis IV, we observed early behavioral deficits which were accompanied by activation of microglia and astrocytes. The glial activation that persisted during the...