نتایج جستجو برای: its founder
تعداد نتایج: 1957525 فیلتر نتایج به سال:
UNLABELLED A population of human immunodeficiency virus (HIV) within a host often descends from a single transmitted/founder virus. The high mutation rate of HIV, coupled with long delays between infection and diagnosis, make isolating and characterizing this strain a challenge. In theory, ancestral reconstruction could be used to recover this strain from sequences sampled in chronic infection;...
Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We present here FounderTracker, a computational method for the genome-wide detection of founder mutati...
In this paper we study some causes and consequences of founder-CEO replacements among a sample of 4,172 Danish startups created by single founders in 1999 and 2000. In contrast to the extant literature on VC-financed firms, replacements among firms in our sample are more likely among the worstand best-performing firms, and replacement is not unambiguously associated with better subsequent perfo...
In Drosophila, much has been learned about the specification of neuronal cell fates but little is known about the lineage of mesodermal cells with different developmental fates. Initially in development, individual mesodermal precursor cells are singled out to become the founder cells for specific muscles. The selection of muscle founder cells is thought to employ a Notch-mediated process of la...
Identifying founder mutations in BRCA1 and BRCA2 in specific populations constitute a valuable opportunity for genetic screening. Several studies from different populations have reported recurrent and/or founder mutations representing a relevant proportion of BRCA mutation carriers. In Latin America, only few founder mutations have been described. We screened 453 Chilean patients with hereditar...
not known. Interestingly, although the founder specification programs act upon the fusion process, the converse does not seem to be true. If the ability of myoblasts to fuse is blocked (for example by mutations in dock180/mbc), then the founder cells still make tiny Manfred Frasch*‡ and Maria Leptin†‡ *Department of Biochemistry and Molecular Biology Mount Sinai School of Medicine One Gustave L...
The Mediterranean basin has been the theater of migration crossroads followed by settlement of several societies and cultures in prehistoric and historical times, with important consequences on genetic and genomic determinisms. Here, we present the Mediterranean Founder Mutation Database (MFMD), established to offer web-based access to founder mutation information in the Mediterranean populatio...
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