A highly regio-, chemo-, diastereo- and enantioselective organocatalytic [4 + 1] annulation of 2-halo-1,3-dicarbonyl compounds with Morita-Baylis-Hillman adducts catalyzed by commercially available, low cost quinidine for the preparation of synthetically unique and medicinally multi-functionalized isoxazoline N-oxides with three stereogenic centers including adjacent quaternary and tertiary ste...

1,3-Dipolar cycloaddition of dihydropyran derived nitrones synthesized from 2,3 dihydro 4H-pyran and various hydroxylamines, with electron deficient alkynes are found to have significant rate acceleration and improved yields of isoxazolines in 1-Butyl-3-methylimidazolium based ionic liquids while with enals exclusively endo isoxazolidines are obtained with high selectivity. Synthetic potentiali...

In this work, we present an efficient one-pot method for the synthesis of three new azo-isoxazoline derivatives (4a–c) from aromatic aldehydes, hydroxylamine hydrochloride and 4-(allyloxy)azobenzene. Thus, were synthesized via 1,3-dipolar cycloaddition using sodium dichloroisocyanurate (SDIC) as eco-friendly inexpensive oxidizing agent under ultrasound cavitation in water a green solvent. The d...

This work presents an examination of the selective functionalization norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization commercially available provided novel bicyclic scaffolds with multiple stereogenic centers. The synthesis involved cycloadditions, subsequent ROM formed cycloalkene-fused isoxazoline an...