Zollinger-Ellison syndrome is a complex condition in which one or more tumors form in the patient's pancreas or upper duodenum. These tumors, called gastrinomas, secrete excessive amounts of gastrin, and almost all develop ulcers. The vast majority of gastrinomas are present within the "gastrinoma triangle," which is composed of the porta hepatis, duodenal sweep, and pancreatic head. As surgery...

Background: Broad spectrum drug screening, also known as systematic toxicological analysis or general unknown screening (GUS), is a method commonly used by clinical and forensic toxicology laboratories to detect a variety of drugs and metabolites in biological fluids. Recently, there has been much interest in liquid chromatography-high resolution mass spectrometry (LCHRMS) techniques for GUS as...

Isotope examination of the liver depends on the functional activity of the liver phagocytes, while ultrasound and CT scanning display the anatomical structure. Cold areas on an isotope scan may be due to impaired function or space-occupying lesions. The method is nonspecific and does not differentiate between cysts, abscesses and metastases. Both ultrasound and CT scanning can differentiate spa...

le Roux, B. T., and Houlder, A. E. (1974). Thorax, 29, 355-358. Gallium-67 as a diagnostic tool in the evaluation of peripheral pulmonary lesions. While Gallium-67 shows a high affinity for primary pulmonary tumours, benign pulmonary lesions also concentrate the isotope. In 50 consecutive patients in whom the diagnosis of pulmonary carcinoma was not achieved by other means, the exhibition of 'G...

Two patients with Herpesvirus hominis (herpes simplex) encephalitis were investigated by serial isotope encephalograms using technetium-99m pertechnetate. In the first case the diagnosis was made by brain biopsy, and by successful tissue culture, and was confirmed by a significant rise in antibody titre, but in the second the laboratory evidence was exclusively serological. Necrotizing encephal...

Scintiscans of liver and spleen using technetium 99m sulphur colloid in 15 infants with extrahepatic biliary atresia and 11 infants with severe obstructive jaundice (7 with genetic deficiency of alpha 1-antitrypsin) showed similar hepatic size, pattern of isotope uptake, and splenic abnormality with no distinguishing features. In 37 older children with a variety of liver disorders, the scan was...

Sources of error in the estimation of ventricular volume from CAT scans are discussed and the accuracy of the measurement assessed. Two methods of calculating ventricular volume from an intraventricular injection of radioisotope are described and compared. Finally, the CAT scan and isotope methods are compared and contrasted. The error associated with a single measurement of volume by any of th...

BACKGROUND Preoperative detection of parathyroid adenoma is a diagnostic challenge. The sonography and computerized tomography (CT) scan demonstrate high sensitivity but low specificity. The advent of radionuclide scanning technique has enhanced the specificity in this context. AIM We undertook a study to assess the role of radionuclide scanning in suspected cases of parathyroid adenomas. M...

The objective of this paper is experimental studies of the linear absorption coefficient, or mean penetration depth of positrons emitted from Na isotope in different materials. For this purpose we constructed a new experimental setup which allows us to scan the depth implantation profile of positrons. For the studied metals: Mg, Al, the obtained values of mean penetration depth coincide well wi...

CASEREPORT A 27 year-old man was admitted with a history ofrightupperquadrant pain, occurring five days after flying home to the United Kingdom fromAustralia via Singapore. Thepainwas constant and throbbing in nature, and was exacerbated by deep inspiration. He had a poor appetite. He gave a history of passing pale stools and dark urine for one week, a number of months previously. He had been i...