• A number of new technics involving external detection of radioactivity in the blood stream or in tissues have been proposed as means for determining the rate, volume and pathway of blood flow in the intact subject. By virtue of their dependence on indirect, external measurement of indicator (isotope) activity in the body as opposed to direct measurement, these technics have been categorized a...

We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. N...

Motivation: Peptide detection is a crucial step in mass spectrometry (MS) based proteomics. Most existing algorithms are based upon greedy isotope template matching and thus may be prone to error propagation and ineffective to detect overlapping peptides. In addition, existing algorithms usually work at different charge states separately, isolating useful information that can be drawn from othe...

Rock powder of dolomite samples from the Renison mine area of Tasmania, Australia were analyzed by electron paramagnentic resonance spectroscopy (EPR), Atomic Absorption and Mass Spectrometer to identify alteration related to mineralisation. The least-altered dolomite samples, which are not effected by circulation of diagenetic and hydrothermal fluids are characterised by low Mn and Fe and ...

An isotope dilution (ID) procedure for the determination of methylmercury (MMHg) in biological samples using an inductively coupled plasma mass spectrometer as detector after the capillary gas chromatographic separation (CGC/ICPMS) has been developed. For the first time, open-focused-microwave pretreatment has been used in conjunction with ID. Optimum conditions for the measurement of isotope r...

Strontium isotopes mimic calcium in their pref erential localization (1—3). Thus 87@Sr has been successfully used for the detection of bone abnor malities, particularly in the early detection of bone forming tumors or bone metastases (4—6). The following case reports demonstrate localiza tion of this isotope in extra-osseous tumors of various histological types. To the best of our knowledge...

We develop and test a model to predict the geographic region-of-origin of humans based on the stable isotope composition of their scalp hair. This model incorporates exchangeable and nonexchangeable hydrogen and oxygen atoms in amino acids to predict the delta(2)H and delta(18)O values of scalp hair (primarily keratin). We evaluated model predictions with stable isotope analyses of human hair f...

After 2004 and 2008 (Vols. 378/2 and 390/2) this is the third issue of Analytical and Bioanalytical Chemistry to contain papers on new developments and applications in isotope ratio measurements. Whereas Klaus Heumann was guest editor for the two previous special issues, in this issue Torsten Schmidt joins him as guest editor for the first time. His involvement with this collection of papers st...