Quinazolinone derivatives are essential units in a wide range of relevant pharmacophores with a broad spectrum of abilities. Due to their wide range of pharmacological and therapeutic activities including anticonvulsant, anti-inflammatory, hypolipidemic, anticancer, and anti-ulcer, the synthesis of quinazolinone moieties as a privileged class of fused heterocyclic compounds, have received much ...

The oxidation of isatins at room temperature, using the cheap and environmentally friendly urea-hydrogen peroxide complex and ultrasonic irradiation, has been investigated. The ultrasonic irradiation dramatically reduces the reaction time. With easy and reproducible reaction procedures, different isatoic anhydrides were obtained in excellent yield and with high purity.

A recent report has indicated that the oxidizing agent Oxone does not possess the ability to cleave the 2,3-carbon-carbon bond of indole. Work in our laboratory shows that this is not the case. Indole and a variety of aryl ring substituted derivatives readily react to form synthetically important isatoic anhydrides.

Quinazolinone derivatives are essential units in a wide range of relevant pharmacophores with a broad spectrum of abilities. Due to their wide range of pharmacological and therapeutic activities including anticonvulsant, anti-inflammatory, hypolipidemic, anticancer, and anti-ulcer, the synthesis of quinazolinone moieties as a privileged class of fused heterocyclic compounds, have received much ...

Purpose: To synthesize and characterize palmitoyl amino benzamides, and to evaluate them for possible anti-inflammatory and anti-nociceptive activities. Methods: Palmitoyl amino benzamides were synthesized by the opening of isatoic anhydride ring with respective amino acids (glycine, β-alanine and γ-aminobutyric acid) and the condensation of the product with palmitoyl chloride. The final produc...

In this work, the influence of three types of styrene maleic anhydride (SMA) oligomers on the adhesion of polystyrene wood plastic composites (WPC) was investigated. The composites were processed on a twin-screw co-rotating extruder below 200°C using 20 wt% of wood flour. The styrene maleic anhydride with different content of maleic anhydride groups, 30%, 25% and 20% (w/w) and levels of 1, 2 an...

The purpose of this paper is to show the effects of level of substitution with a linear chain anhydride (propionic anhydride) on decay resistance and on water vapour sorption of modified Scots pine sapwood. The work described herein has demonstrated that chemically modified Scots pine sapwood with propionic anhydride afforded substantial bioprotection against Coniophora puteana. It required a w...