Although the pathophysiology of chronic urticaria is not fully understood, it is possible that dysfunctioning of peripheral cutaneous nerve fibres may be involved. It has also been suggested that fibromyalgia syndrome, a multi-symptomatic chronic pain condition, may be associated with alterations and dysfunctioning of peripheral cutaneous nerve fibres. The aim of this study was to determine whe...

EditorIals authors state that they think the increase in responsiveness observed in their patients was simply the result of cigarette smoking, but they do not examine this question. Thus, the origin of the increase in responsiveness and its relationship to atopy and cigarette smoking are not clarified by their investigation. The major problem with all existing longitudinal work published on inc...