BACKGROUND Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim of this study was to estimate the heritability in serum iron parameters explained by HFE. METHODS Ninety families (980 subjects) were included in the present analysis. Heritability estimation was conducted using the variance ...

Indeed, when the iron content of liver biopsies from HCV-infected patients was measured, there was only a real increase in hepatic iron in 10% of the cases, despite a rise in serum ferritin and transferrin saturation.8 It should be pointed out that cytolysis could have led to the increase in both serum ferritin and transferrin saturation. In conclusion, it is unlikely that the C282Y mutation of...

BACKGROUND A microwell modification of the bleomycin assay for determining non-transferrin-bound iron (NTBI) was evaluated and compared with a chelation method. METHODS The bleomycin assay reagent and sample volumes were halved, and measurements were done in microwell plates. Samples from patients treated for hematologic malignancies were studied. The chelation method was based on mobilizatio...

The ability of Staphylococcus epidermidis strains to grow in the presence of human transferrin and varying amounts of ferric iron was studied. At initial bacterial densities up to 10(4) cfu ml(-1), none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non...

Iron oxide nanoparticles were synthesized by coprecipitation method using ammonia as precipitation agent. Most researchers usually add ammonia into the iron salt solution but in this work the salt solution drop wise has been added to the ammonia and the new obtained results were compared with those of other researches. Magnetic properties of nanoparticles were measured by VSM. The effect of rea...

Background: As it is difficult to know the content of iron added in the Brazilian iron fortification of wheat and corn flour, and if the compound has good or poor bioavailability, the objective was to assess the effect of the Brazilian iron fortification program, as it was carried out, on iron nutritional status of adolescents, 6 years after its implementation. Methods: A cross-sectional retros...

In previous analyses of transferrin saturation data in African Americans and Caucasians from the second National Health and Nutrition Examination Survey (NHANES II), subpopulations were found consistent with population genetics for common loci that influence iron metabolism. The goal of this new study was to determine if these transferrin saturation subpopulations have different levels of iron ...

Natural resistance-associated macrophage protein 1 (Nramp1) is a divalent metal transporter expressed exclusively in phagocytic cells. We hypothesized that macrophage Nramp1 may participate in the recycling of iron acquired from phagocytosed senescent erythrocytes. To evaluate the role of Nramp1 in vivo, the iron parameters of WT and KO mice were analyzed after acute and chronic induction of he...

Iron oxide nanoparticles were synthesized by coprecipitation method using ammonia as precipitation agent. Most researchers usually add ammonia into the iron salt solution but in this work the salt solution drop wise has been added to the ammonia and the new obtained results were compared with those of other researches. Magnetic properties of nanoparticles were measured by VSM. The effect of rea...

In previous analyses of transferrin saturation data in African Americans and Caucasians from the second National Health and Nutrition Examination Survey (NHANES II), subpopulations were found consistent with population genetics for common loci that influence iron metabolism. The goal of this new study was to determine if these transferrin saturation subpopulations have different levels of iron ...