Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants. Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins. Grx5 localizes at the...

Tryptophan hydroxylase (TPH), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5-HT), is irreversibly inactivated by nitric oxide (NO). We have expressed brain TPH as a recombinant glutathione-S-transferase fusion protein and delineated the catalytic domain of the enzyme as the region spanning amino acids 99-444. Highly purified TPH catalytic core, lik...

We demonstrate giant magnetoresistance in Fe/MoS2/Fe junctions by means of ab initio transport calculations. We show that junctions incorporating either a monolayer or a bilayer of MoS2 are metallic and that Fe acts as an efficient spin injector into MoS2 with an efficiency of about 45%. This is the result of the strong coupling between the Fe and S atoms at the interface. For junctions of grea...

Iron (II) disulfide (FeS2) is a semiconductor which belongs to the space group 6 3 h T Pa  . It has a cubic crystal system (primitive cubic). Iron (II) disulfide is used in Lithium metal sulfide batteries, solar photovoltaics, battery recycling and molding compounds. It has a narrow band gap value of 0.95 eV [1]. Tellurium (Te) is classified as metalloid (p-type semiconductor) and belongs to t...

We present new methods for identifying and analyzing statistically significant residue clusters that occur in three-dimensional (3D) protein structures. Residue clusters of different kinds occur in many contexts. They often feature the active site (e.g., in substrate binding), the interface between polypeptide units of protein complexes, regions of protein-protein and protein-nucleic acid inter...

hormone replacement therapy in postmenopausal women did not significantly alter ferritin concentrations. Whether this is because of different dosage schedules of the estrogens used or because of less blood loss in postmenopausal women has to be further evaluated. When subjects donated blood on a regular basis, a significantly lower ferritin concentration could be observed for men (x 5 23.242; P...

A new dissymmetrically disubstituted diiron dithiolate species, [Fe(2)(CO)(4)(κ(2)-P(Ph)(2)N(Ph)(2))(μ-pdt)] (pdt = S(CH(2))(3)S), was prepared by using a flexible cyclic base-containing diphosphine, 1,3,5,7-tetraphenyl 1,5-diaza-3,7-diphosphacyclooctane (P(Ph)(2)N(Ph)(2) = {PhPCH(2)NPh}(2)). Preliminary investigations of proton and electron transfers on the diiron system have been done.

Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic various diseases. To specifically deliver iron to macrophages, oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, cores act as c...