Background: Deferasirox (DFX), Deferoxamine (DFO), and Deferiprone (DFP) are iron chelators that can be used in thalassemic patients with iron overload. Materials and Methods: This clinical trial was performed on 108 thalassemic patients who were randomly divided into group A (n=54) and B (n=54). Group A received combination of DFX and DFP, and group B received DFO and DFP for six months. Seru...

the effects of confinement in carbon nanotubes on fischer-tropsch (ft) activity, selectivity and lifetime of carbon nanotubes (cnts) supported iron catalysts are reported. a method was developed to control the position of the catalytic sites on either inner or outer surface of carbon nanotubes. tem analyses revealed that more than 80% of iron oxide particles can be controlled to be positioned a...

Iron depositions, one of the non-transferrin-bound iron (NTBI), are frequently observed for the patients with hemochromatosis and several neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, etc. In this article, we have showed that iron deposition formation on the albumin proceeds in two different ways, one of them contains the participation of hydrogen peroxide, and the ...

Scanning tunneling microscopy (STM) has been used to investigate the nucleation and stability of iron clusters on the Al2O3/ Ni3Al(111) surface as a function of coverage and annealing temperature. We show that atomic beam deposition of iron leads to hexagonally ordered cluster arrangements with a distance of 24 Å between the clusters evidencing the template effect of the alumina film. The shape...

BACKGROUND Failed hip prostheses can cause elevated circulating cobalt and chromium levels, with rare reports of fatal systemic organ deposition, including cobalt cardiomyopathy. Although blood cobalt and chromium levels are easily measured, organ deposition is difficult to detect without invasive biopsy. The T2* magnetic resonance (MR) method is used to quantify tissue iron deposition, and pla...

BACKGROUND Increased iron deposition has been implicated in the pathophysiology of multiple sclerosis (MS), based on visual analysis of signal reduction on T(2)-weighted images. R(2)* relaxometry allows to assess brain iron accumulation quantitatively. OBJECTIVE To investigate regional brain iron deposition in patients with a clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS)...

Neonatal hemochromatosis (NH) is an acute liver disease associated with both hepatic and extrahepatic iron deposition and is a leading cause of neonatal liver transplantation. The concept that NH is an alloimmune disease has led to the emergence of a new treatment approach utilizing exchange transfusion and intravenous immunoglobulin therapy. We present a two-day old neonate with progressive li...

Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be eluci...

Introduction: Precise and effective measurements of iron overload in the liver, where iron deposition seems to be primarily noticeable [1], are important for the early diagnosis, treatment and follow-up of thalassemia patients. Measurement of liver iron concentration in a small part of a needle biopsy is currently considered the gold standard for this purpose and is taken as representative of t...

Objective: To determine if chemical shift imaging is comparable to single-echo T2*-weighted imaging in the quantification of hepatic iron, and if coexisting steatosis affects its performance. Design: Retrospective analysis. Participants/Methods: This study was comprised of 63 patients (50 men and 13 women) who had undergone MRI of the liver and concomitant histopathologic analysis within 90 day...