Zinc interfered with translocation of iron from roots to above ground parts of Glycine max. (L.) Merrill var. Hawkeye. During periods in which zinc impeded iron translocation, it also suppressed the production of reductant by roots. Addition of iron, as a ferric metal chelate (iron ethylenediaminedihydroxyphenylacetic acid), to the growth medium overcame the interference of zinc. In the root ep...

OBJECTIVE To determine if repletion of hemoglobin was achievable in young children presenting both severe (< or =9.4 g hemoglobin/dL blood) and less severe iron deficiency anemia (9.5 to 11.0 g hemoglobin/dL blood) through fortification of liquid 3.3% butterfat milk with a bioavailable ferrous iron amino acid chelate (Ferrochel) at 3 mg iron/liter/day. METHODS A group of 185 children were sel...

Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revea...

Fe(III) oxides hydrated to various extents are the most abundant iron species in soil. Their extremely low solubility makes them almost unavailable to living organisms. To cope with iron deficiency, many microorganisms synthesize and secrete siderophores [1–5], which are low-molecular-weight compounds that specifically chelate Fe(III) to form stable complexes, into the soil (association constan...

Previous studies documented the abnormal association of heme and heme proteins with the sickle RBC membrane. We have now examined RBC ghosts and inside-out membranes (IOM) for the presence of nonheme iron as detected by its formation of a colored complex with ferrozine. Sickle ghosts have 33.8 +/- 18.2 nmol nonheme iron/mg membrane protein, and sickle IOM have 4.3 +/- 3.0 nmol/mg. In contrast, ...

iron deficiency in soil reduces the quality of durum wheat leading to fe deficiency in human. thus, this experiment investigated the effects of foliar application of nano-iron oxide (2 and 4 g l-1), iron chelate (edta), (4 and 8 g l-1), iron sulfate (4 and 8 g l-1), and the control on grain yield and quality, yield components, chlorophyll and carotenoids contents, peroxidase (pox), catalase (ca...

Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nit...

Iron (Fe) is an essential micronutrient for human growth and health. Organic iron is an excellent iron supplement due to its bioavailability. Both amino acids and peptides improve iron bioavailability and absorption and are therefore valuable components of iron supplements. This review focuses on protein hydrolysates as potential promoters of iron absorption. The ability of protein hydrolysates...

Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetriaminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) ...