Activation of neutrophils by phagocytosis or certain soluble stimuli results in a burst of oxidative metabolism and in degranulation. Fluoride is known to trigger the metabolic burst. but degranulation has not been reported. lodination of protein by F -activated human PMN was demonstrated by measuring TCA-precipitable 1251. lodination was dependent on H20,. since it was inhibited by catalase. e...

An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including bio...

A discontinuous gradient of Percoll was used to remove RBCs from polymorphonuclear leucocyte (PMN) preparations. The resulting red blood cell-free preparation was used to investigate the effect of ammonium chloride on the iodination response of human PMN. Treatment of PMN with ammonium chloride for five minutes at room temperature resulted in a statistically significant increase in the iodinati...

1. A method is described for the trace iodination of immunoglobulins and other serum proteins by a system consisting of lactoperoxidase, hydrogen peroxide and iodide. 2. gammaG immunoglobulin that had been labelled to a specific radioactivity of 5muc/mug. by use of carrier-free [(125)I]iodide gave no evidence of denaturation when analysed by electrophoresis and density-gradient ultracentrifugat...

A double labeling procedure was employed to determine whether the tyrosine residues in thyroglobulin that are iodinated first are also those that are most readily converted to thyroxine. Goiter thyroglobulin containing less than 1 atom of iodine per molecule was iodinated first with 9 at relatively low levels of iodination (5 to 20 atoms of iodine per molecule) and afterward with lzjI at higher...

Introduction The conversion of tyrosyl residues into iodo-derivatives can be brought about under different ex­ perimental conditions [1 -3 ] and is essentially an electrophilic substitution by iodine at the phenolic ring of tyrosine. This reaction has been performed for different purposes in protein chemistry, e.g. the iodination of tyrosine has been extensively used in the preparation of label...

The iodination of chlorinated aromatic compounds using Ag(2)SO(4)/I(2), AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2) offers access to iodoarenes that are valuable intermediates in organic synthesis. Specifically, iodination of phenols, anisoles and anilines with a 3,5-dichloro substitution pattern preferentially yielded the ortho, para and para iodinated product, respectively. In the case of ch...