Being able to scale preclinical pharmacodynamic response to clinical would be beneficial in drug development. In this work, the integrated glucose insulin (IGI) model, developed on clinical intravenous glucose tolerance test (IVGTT) data, describing dynamic glucose and insulin concentrations during glucose tolerance tests, was scaled to describe data from similar tests performed in healthy rats...

The insulin sensitivity index (SI) can be used in assessing the risk of developing type 2 diabetes. An intravenous study is used to determine SI using Bergmans minimal model. However, an intravenous study is time consuming and expensive and therefore not suitable for large scale epidemiological studies. In this paper we learn the parameters and structure of several Bayesian networks relating me...

BACKGROUND Modeling studies of the insulin-glucose relationship have mainly utilized parametric models, most notably the minimal model (MM) of glucose disappearance. This article presents results from the comparative analysis of the parametric MM and a nonparametric Laguerre based Volterra Model (LVM) applied to the analysis of insulin modified (IM) intravenous glucose tolerance test (IVGTT) da...

OBJECTIVE To quantify the degree of plasma volume expansion that occurs during an intravenous glucose tolerance test (IVGTT). METHODS Twenty healthy volunteers (mean age, 28 years) underwent IVGTTs in which 0.3 g/kg of glucose 30% was injected as a bolus over 1 min. Twelve blood samples were collected over 75 min. The plasma glucose and blood hemoglobin concentrations were used to calculate t...

The classic (hereafter cold) and the labeled (hereafter hot) minimal models are powerful tools to investigate glucose metabolism. The cold model provides, from intravenous glucose tolerance test (IVGTT) data, indexes of glucose effectiveness (SG) and insulin sensitivity (SI) that measure the effect of glucose and insulin, respectively, to enhance glucose disappearance and inhibit endogenous glu...

The minimal model approach to estimating insulin sensitivity (Sl) and glucose effectiveness in promoting its own disposition at basal insulin (SG) is a powerful tool that has been underutilized given its potential applications. In part, this has been due to its inability to separate insulin and glucose effects on peripheral uptake from their effects on hepatic glucose inflow. Prior enhancements...

Oral glucose tolerance test with 50g glucose was carried out with and without simultaneous oral administration of 3g calcium lactate. Blood sugar and serum immunoreactive insulin (IRI) were measured before and 30, 60, 90 and 120min after glucose load in 11 diabetics and 11 non-diabetics. Similar oral glucose tolerance test was performed with and without intravenous administration of 10ml 8.5% c...

The two-compartment minimal model (2CMM) interpretation of a labeled intravenous glucose tolerance test (IVGTT) is a powerful tool to assess glucose metabolism in a single individual. It has been reported that a derived 2CMM parameter describing the proportional effect of glucose on insulin-independent glucose disposal can take physiologically unplausible negative values. In addition, precision...

Introduction: Repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. Endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. The aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. Me...

INTRODUCTION The aim of this study was to evaluate beta-cell function and insulin resistance in relation to the occurrence of anti-islet antibodies in first degree relatives of patients with type 1 diabetes (T1D). MATERIAL AND METHODS The group studied consisted of 90 relatives and 60 healthy individuals without a family history of diabetes. An intravenous glucose tolerance test (IVGTT) was p...