A 70-year-old woman was admitted to our hospital because of sudden hearing loss. She was treated with intratympanic dexamethasone, but her hearing impairment progressed. After admission, she developed scleritis of her left eye. Laboratory findings included elevated white blood cell count and C-reactive protein level, microhematuria, and proteinuria. Serology was positive for myeloperoxidase ant...

OBJECTIVES/HYPOTHESIS Dexamethasone is widely used in the treatment of various inner ear diseases. However, knowledge about its direct impact on glucocorticoid receptor (GR) expression is still limited. STUDY DESIGN Prospective animal study in male guinea pigs. METHODS A therapeutic concentration of dexamethasone (8 mg/mL) or a physiological concentration of NaCl (0.9% solution) were intrat...

OBJECTIVE To evaluate safety and efficacy of a single intratympanic injection of OTO-104, sustained-exposure dexamethasone, in patients with unilateral Ménière's disease. STUDY DESIGN Randomized, double-blind, placebo-controlled, Phase 2b study over 5 months. SETTING Fifty-two academic and community otolaryngology centers. PATIENTS One hundred fifty four patients (77 per group) aged 18 to...