After a search on Medline, it appears that intraperitoneal injection of sodium pentobarbitone is often used for anaesthesia and euthanasia of rodents. In the present pilot study in rats, spinal nociception after intraperitoneal injection of sodium pentobarbitone, with and without lidocaine, was examined by estimation of the number of c-fos-expressing neurones in the spinal dorsal horn. One grou...

BACKGROUND Postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy (LC) has multifactorial etiology. Pain and use of opioids are among the important factors. OBJECTIVES The present study aimed to evaluate the efficacy of intrapritoneal (IP) injection of bupivacaine on PONV. PATIENTS AND METHODS This was a double-blind randomized clinical trial, conducted on 66 patients a...

 ABSTRACT Background: Postoperative pain is an important surgical problem. Recent studies in pain pathophysiology have led to the hypothesis that with perioperative administration of analgesics (pre-emptive analgesia) it may be possible to prevent or reduce postoperative pain. This study was planned to investigate the efficacy of pre-emptive analgesia on postoperative pain after major gynecolog...

Objective: To evaluate the effects of preincisional infiltration and intraperitoneal instillation of bupivacaine on early relief of pain after diagnostic laparoscopy. Design: Randomized, placebo, controlled-double blind study Setting: University teaching hospital. Materials and methods: Sixty three women with unexplained infertility, for whom diagnostic laparoscopy was performed under general a...