In order to determine whether oxytocin release is controlled by an osmoreceptor mechanism identical with that for vasopressin release, the plasma oxytocin concentration and plasma osmolality were measured during intraatrial infusion and after intraventricular injection of various osmotic solutions in unanesthetized rats. Intraatrial infusion of 0.6 M NaCl Locke solution (L.S.) or 1.2 M mannitol...

The aim of the present study was to further examine the efficacy of different doses and routes of D-cloprostenol and cloprostenol administration on the parturition response in sows. Ninety crossbred multiparous sows (Landrace x Yorkshire) with an average parity number of 4.3 ± 2.4 were allocated to induce farrowing by one of the following treatments: Gr. 1 (control, n=10) injection with normal ...

Cervical stimulation induces two daily rhythmic prolactin surges, nocturnal and diurnal, which persist for several days. We have shown that a bolus injection of oxytocin initiates a similar prolactin rhythm, which persists despite low levels of oxytocin after injection. This suggests that oxytocin may trigger the cervical stimulation-induced rhythmic prolactin surges. To investigate this hypoth...

Background: Musculoskeletal pain is a major clinical problem, but researchers lack viable animal models to study this phenomenon. However, formalin injections are widely used to produce tonic and neurogenic nociceptive responses in rodents. Rodents can present a potential animal model for pain. Objectives: To develop a muscle pain model with intramuscular injection of formalin in rats. Ma...

Objective(s): Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on inflammatory pain. The contribution of opiate receptors was explored using non-selective and selective antagonists. Materials and Methods: The fourth ventricle of the brain of anesthetized rats was impla...

Systemic administration of beta(2)-adrenoceptor agonists (beta(2)-agonists) can improve skeletal muscle regeneration after injury. However, therapeutic application of beta(2)-agonists for muscle injury has been limited by detrimental cardiovascular side effects. Intramuscular administration may obviate some of these side effects. To test this hypothesis, the right extensor digitorum longus (EDL...

background: musculoskeletal pain is a major clinical problem, but researchers lack viable animal models to study this phenomenon. however, formalin injections are widely used to produce tonic and neurogenic nociceptive responses in rodents. rodents can present a potential animal model for pain. objectives: to develop a muscle pain model with intramuscular injection of formalin in rats. material...

OBJECTIVES Analgesic effects of oxytocin and it's the other physiological effects were well-known. The aim of present study was determination of nitric oxide role on analgesic effects of oxytocin in mice. MATERIALS AND METHODS 216 male Albino mice were divided randomly into two experimental groups, tail flick and formalin test. Each experimental group consists of three main groups including: ...

Intramuscular injection of vaccines and medications into the deltoid muscle is a long-established nursing practice. The deltoid muscle is the preferred site for intramuscular injections to adult clients in community settings, as it requires minimal, generally socially-acceptable, exposure of the client’s body, and is easily accessible to the professional administering the injection. Nursing stu...