OBJECTIVE Intrahepatic cholestasis of pregnancy (ICP) complicates pregnancies which is characterized by elevated serum bile acid levels. ICP increases maternal and fetal morbidities. This study was designed to determine the association of maternal and fetal complications and serum bile acid levels. MATERIAL AND METHOD Maternal and fetal characteristics were analyzed from the medical records o...

Hepatobiliary transport systems mediate hepatic uptake and biliary excretion of bile acids, bilirubin and other biliary constituents. Hereditary or acquired defects of these transporters may cause or maintain cholestasis and jaundice under various clinical conditions including progressive familial intrahepatic cholestasis (PFIC) 1-3 or its milder forms, benign recurrent intrahepatic cholestasis...

The liver plays pivotal roles in immunologic responses, and correct hepatic adaptations maternal immunology are required during pregnancy. In this review, we focus on anatomical immunological pregnancy, including our recent reports area. Moreover, summarize pregnancy-associated diseases, hyperemesis gravidarum; intrahepatic cholestasis of pregnancy; preeclampsia, specifically hemolysis, elevate...