PURPOSE To determine whether long-term brimonidine (BRI) treatment prevents the hyperglycemia-induced increase in vitreoretinal vascular endothelial growth factor (VEGF) expression and breakdown of the blood-retinal barrier (BRB) in streptozotocin (STZ)-induced diabetic rats. METHODS Brown Norway/Long-Evans rats were divided into three groups with similar distributions of blood glucose and bo...

purpose: to report a case of ciliary body medulloepithelioma presenting as granulomatous uveitis.   patient and finding: a 3-year-old girl presented with chronic granulomatous anterior uveitis in the right eye following unilateral cataract extraction and iol implantation which was unresponsive to topical steroids and intra-vitreal injection of vancomycin and triamcinolone acetonide. one month l...

The present study was carried out to delineate the ocular pharmacokinetics of ganciclovir (GCV) following intravitreal administration. Another objective was to achieve sustained therapeutic concentrations of GCV in the vitreous over a prolonged period of time using its acyl monoester prodrugs (acetate, propionate, butyrate, and valerate). New Zealand albino male rabbits (2-2.5 kg) were kept und...

PURPOSE To study the acute effects of L-ornithine hydrochloride on the function of cat retina in vivo. METHODS A small amount of ornithine was administered intravitreously or intravenously. Changes in retinal function were monitored by vitreal electroretinogram (ERG) and intraretinal ERG with K(+)-selective microelectrodes. RESULTS Intravitreal injections (0.2 to 0.5 M; 15 microliters) of o...

PURPOSE To determine the extent and the mechanism by which topotecan, a candidate agent for the treatment of retinoblastoma, gains access to the vitreous when administered by periocular injection or intravenous infusion. METHODS In vivo experiments were conducted in which albino rabbits received 1 mg topotecan by periocular injection (POI group; n = 30) or as a 30-minute intravenous infusion ...

INTRODUCTION We report a case of early lactobacillus endophthalmitis which occurred ten days after trabeculectomy. CASE PRESENTATION A 76-year-old Caucasian diabetic woman underwent uncomplicated trabeculectomy with a collagen implant as an adjunct, in her left phakic eye, for the treatment of uncontrolled open-angle glaucoma. Ten days post-operatively, our patient complained of left phakic e...

Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves or spinal cord are involve...

PURPOSE To investigate the hypothesis that the pathophysiology for the death of retinal ganglion cells in glaucoma involves excitotoxic effects from elevated concentrations of vitreal glutamate. METHODS Experimental glaucoma was induced in the right eyes of 18 rhesus monkeys by argon laser treatments to the trabecular meshwork. After significant visual field defects and/or typical clinical gl...