INTRODUCTION Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated the efficacy of bevacizumab, an antibody against vascular endothelial growth factor and an inhibitor of angiogenesis, in the treatment of OA using a rabbit model of anterior cruciate ligament transection. METHODS First, we evaluated the response of gene expression and histology of the n...

BACKGROUND Candida spp. are dimorphic fungi in the family Cryptococcaceae. Infections with Candida spp. are usually rare conditions in dogs, but immunocompromised patients have a higher risk for developing invasive candidal infections. CASE PRESENTATION A 5-year-old male Boxer, positive to Leishmania infantum, was referred to the Veterinary Teaching Hospital of the Department of Veterinary Me...

The number of total knee arthroplasties (TKA) performed is around two million annually worldwide and this number is expected to increase fivefold by 2025. The most common indication is osteoarthritis of the knee. Blood loss is significant during the post-operative period and blood transfusion when necessary has its own drawbacks. The use of intravenous tranexamic acid has significantly reduced ...

OBJECTIVES The goal of this study was to determine whether intra-articular administration of the potentially anti-fibrotic agent decorin influences the expression of genes involved in the fibrotic cascade, and ultimately leads to less contracture, in an animal model. METHODS A total of 18 rabbits underwent an operation on their right knees to form contractures. Six limbs in group 1 received f...

Providing suitable analgesia following diagnostic and therapeutic arthroscopic surgeries, that areconsidered to cause some degree of postoperative pain, is a necessity in equine practice. The aim of thepresent study was to evaluate the equine synovial fluid biochemical and cytological changes as well asclinical assessments of the joint following intra-articular administration of ketamine. Six a...

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