The aim of this study is to evaluate the carotid artery intima media thickness and serum lipids in pediatric patients with epilepsy treated with valproic acid. The study included 44 pediatric epileptic and 40 healthy children. Intima media thickness of left common carotid artery and fasting lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipopr...

Atherosclerosis develops chiefly in the intima of the artery. Biochemical changes associated with atheromatosis were studied serially in human aortic intima by a gross division of the intima into normal tissue, early and advanced atheromata. Earliest alterations observed are increases in collagen concentration and in binding of hexosamine with scleroprotein. Elevation of lipids occurs only afte...

OBJECTIVE To describe and test a practical protocol to measure common carotid intima-media thickness that uses the combined values of two longitudinal examination angles to increase sensitivity. METHOD Between February and September 2005, 206 patients underwent duplex scan examination of carotid vessels, and the intima-media thickness of 407 common carotids were measured in three angles: tran...

objective: duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. intima media thickness (imt) is appropriate for atherosclerosis process diagnosis. leukoaraisis (la) increase the risk of cerebrovascular accident (cva). la patients need preventive medication for cva. imt is a non-invasive diagnostic and prognostic test in la. the aim of this study was evalua...

objective: atherosclerosis disease, inflammation and malnutrition have strong association with end stage renal disease (esrd). diabetes mellitus (dm) is the most commonly esrd causes. diabetic nephropathy (dn) could be associated with inflammation. type 2 diabetic patients with advanced nephropathy show the highest levels of inflammatory markers. this study was designed to determine the associa...

INTRODUCTION The measurement of carotid artery intima-media thickness in children and adolescents has attracted a great deal of research and clinical interest in recent years, because it can provide evidence that early arterial lesions are already present in asymptomatic subjects who have risk factors for cardiovascular disease. The aim of the present study was to investigate possible correlati...

Current methods for assessing the intima of pulmonary arteries produce measurements of intima and artery size that are affected by the constriction or collapse of the arteries and the generally patchy distribution of intimal abnormality. Our new method measures intimal area and defines artery size as the total length of the internal elastic lamina; these measurements are unaffected by the const...

We have measured the levels of glycosphingolipids and the activity of glycosphingolipid glycosyltransferases in human aortic intima and media from patients who died of atherosclerosis. The effects of lactosylceramide (LacCer) and glucosylceramide (GlcCer) from plaque intima on smooth muscle cell proliferation were assessed. When the GlcCer data was expressed as (micrograms GlcCer/mg cholesterol...

Atherosclerotic plaque rupture is recognized as the primary cause of cardiac and cerebral ischaemic events. High structural plaque stresses have been shown to strongly correlate with plaque rupture. Plaque stresses can be computed with finite-element (FE) models. Current FE models employ homogeneous material properties for the heterogeneous atherosclerotic intima. This study aimed to evaluate t...

BACKGROUND Ultrasonographic assessments of intima-media thickness and plaques in the carotid artery are widely used as surrogate markers for coronary atherosclerosis, but prospective evaluations are scarce and appear to be lacking in patients with coronary artery disease. Ultrasonographic evaluations of femoral vascular changes have not been studied prospectively. METHODS AND RESULTS In the A...