Thoracolumbar intervertebral disc disease is the most common cause of caudal paresis in dogs. Whilst the pathogenesis of the extrusion has been widely studied, treatment protocols and prognostic factors relating to outcome remain controversial. Recent studies have examined a multitude of factors relating to time to regain ambulation after decompressive surgery. Most intervertebral disc herniati...

Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new histological classification applicable to an in vivo mouse intervertebral disc degeneration model induced by needle puncture. One hundred six mice were operated and the L4/5 intervertebral disc was punctured with a 35- or 33-gauge needle. Micro-...

Intervertebral disc degenerative diseases have become a serious social health problem. However, there is no clinical treatment effectively retarding the progression of intervertebral disc degeneration. Crocin, which is extracted from saffron, has been proved to exert anti-inflammatory and anti-catabolic effects on intervertebral disc in vitro and ex vivo. In the present study, effects of crocin...

Background To determine the relationship between superior disc-endplate complex injury and correction loss after surgery in a group of young adult patients with a stable thoracolumbar burst fracture. Methods The study group was comprised of young adult patients who had undergone short-segment posterior fixation and bone grafting under the diagnosis of a stable thoracolumbar burst fracture fro...

Degeneration of the intervertebral disc is implicated as the main cause of low back pain. Current treatment strategies for degenerative disc disease, such as conservative treatments and surgeries, only relieve the symptoms of low back pain without treating the causes of underlying degeneration. Surgical treatments cannot reverse the degeneration of the intervertebral disc degeneration, and may ...

Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of...

Objective To evaluate the occurrence and frequency of abnormalities at the second and third cervical vertebral junction (C2/3) in dogs with and without atlantoaxial instability (AAI). Study Design Retrospective multi-institutional case-controlled case series. Animals One hundred and seventeen dogs with AAI and 117 dogs without AAI. Methods Radiographs, together with computer tomographic images ...

This review article describes anatomy, physiology, pathophysiology and treatment of intervertebral disc. The intervertebral discs lie between the vertebral bodies, linking them together. The components of the disc are nucleus pulposus, annulus fibrosus and cartilagenous end-plates. The blood supply to the disc is only to the cartilagenous end-plates. The nerve supply is basically through the si...

Degenerative spinal disorders including low back pain are one of the most common and costly problems for modern society. It has been recognized that these disorders are directly or indirectly associated with intervertebral disc degeneration. The disc is a cartilaginous connective tissue, composed of the nucleus pulposus(NP), annulus fibrosus and endplates, which connects adjacent vertebrae (the...

Cervical intervertebral disc herniation, or a slipped disc, is a common orthopedic disease in canines. The standard surgical treatment used to relieve the herniation is the ventral slot technique, wherein a small slot is created by drilling into a neighboring vertebral body and the intervertebral space to relieve the pressure. However, the defects created in the disc, vertebral body, and adjace...