BACKGROUND The ImmunoDeficiency Resource (IDR) is a knowledge base for the integration of the clinical, biochemical, genetic, genomic, proteomic, structural, and computational data of primary immunodeficiencies. The need for the IDR arises from the lack of structured and systematic information about primary immunodeficiencies on the Internet, and from the lack of a common platform which enables...

BACKGROUND Interdisciplinary rounds (IDR) with documentation have become a standard of care, but the process has been incompletely described in academic general medical settings. Checklists are promoted, yet standardized formats may not reflect the variability and work flow of rounds or support the cognitive development of medical trainees. We describe IDR processes in an academic general medic...

Excessive influx and the subsequent rapid cytosolic elevation of Ca2+ in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regulate cytosolic Ca2+ level in normal as well as pathological conditions. Delayed rectifier K+ channel...

Innate defense regulator-1 (IDR-1) is a synthetic peptide with no antimicrobial activity that enhances microbial infection control while suppressing inflammation. Previously, the effects of IDR-1 were postulated to impact several regulatory pathways including mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein, but how this was mediated was unknown. Using a combined s...

Regulation of the immune system by immunomodulatory agents, such as the synthetic innate defense regulator (IDR) peptides, has been proposed as a potential strategy to strengthen host immune responses against infection. IDR peptides confer protection in vivo against a range of bacterial infections and have been developed as components of single-dose vaccine adjuvants due to their ability to mod...

Abstract The Duano Tribe are fishermen that run fishing businesses traditionally. Generally, they use longlines and drift gill nets equipment for fishing. purpose of this research is to analyze the income based on main catch Belanak Senangin fish contribution business total fisherman income. descriptive method author used where data were collected from 29 Tribe. This was conducted in Tanjung Pa...

Peptide motifs embedded within intrinsically disordered regions (IDRs) of proteins are often the sites of posttranslational modifications that control cell-signaling pathways. How do IDR sequences modulate the functionalities of motifs? We answer this question using the polyampholytic C-terminal IDR of the cell cycle inhibitory protein p27(Kip1) (p27). Phosphorylation of Thr-187 (T187) within t...

IDR(s) is one of the most efficient methods for solving large sparse nonsymmetric linear systems of equations. We present two useful extensions of IDR(s), namely a flexible variant and a multi-shift variant. The algorithms exploit the underlying Hessenberg decomposition computed by IDR(s) to generate basis vectors for the Krylov subspace. The approximate solution vectors are computed using a Qu...

The IDR method of Sonneveld and van Gijzen [SIAM J. Sci. Comput., 31:1035–1062, 2008] is shown to be a Petrov-Galerkin (projection) method with a particular choice of left Krylov subspaces; these left subspaces are rational Krylov spaces. Consequently, other methods, such as BiCGStab and ML(s)BiCGStab, which are mathematically equivalent to some versions of IDR, can also be interpreted as Petro...

Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine bactenecin. We showed that IDR-1 and IDR-1002 protect the host against bacterial...