The management of diabetic neuropathy (DN) is still a challenge for physicians. Hyperglycemia induced oxidative stress involves in the development of diabetic neuropathy, which could be reversed by supplementation of antioxidants. In the present study, it has targeted the oxidative stress mediated nerve damage in DN by using combined therapy of rutin (RT) and silymarin (SM). Diabetes was induce...

Type one diabetes mellitus (T1DM) is an autoimmune condition wherein islet cells of pancreas are damaged, necessitating extrinsic insulin therapy for the remainder life. T1DM affects kids and teenagers accounts roughly 5-10% cases. Cytokines low-molecular-weight extracellular molecules that serve as immune modulators which cause β impairment in patients by generating nitric-oxide. Comprehending...

Butenolides are a family of lactones containing double bond and have been frequently found in the extracts Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered isolated from culture broth marine-derived sp. 13G036 based on molecular networking analysis. Among isolates, compound 7 was first as natural product study. The st...