نتایج جستجو برای: interleukin 2

تعداد نتایج: 2587153  

Journal: :Science 2005
Mathias Rickert Xinquan Wang Martin J Boulanger Natalia Goriatcheva K Christopher Garcia

Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-sw...

Journal: :The New England journal of medicine 2007
David A Hafler Alastair Compston Stephen Sawcer Eric S Lander Mark J Daly Philip L De Jager Paul I W de Bakker Stacey B Gabriel Daniel B Mirel Adrian J Ivinson Margaret A Pericak-Vance Simon G Gregory John D Rioux Jacob L McCauley Jonathan L Haines Lisa F Barcellos Bruce Cree Jorge R Oksenberg Stephen L Hauser

BACKGROUND Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. METHODS We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication,...

Journal: :international journal of reproductive biomedicine 0
mustafa yen orkide donma ferdag yildizfer ozlem ekmekci asli karatas kul a. esat imal

background: possible roles of anti-inflammatory factors as well as total antioxidative capacity in reproductive processes of women undergoing in vitro fertilization (ivf) are still being investigated and the contributions by some of them remain controversial. objective: the aim of this study is to investigate the relationship between anti-inflammatory parameters and total antioxidative capacity...

Journal: :JNCI Journal of the National Cancer Institute 1992

Journal: :The Journal of Infectious Diseases 2009

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